Survivin Loss in Thymocytes Triggers p53-mediated Growth Arrest and p53-independent Cell Death

Survivin Loss in Thymocytes Triggers p53-mediated Growth Arrest and p53-independent Cell Death

Because survivin-null embryos die at an early embryonic stage, the role of survivin in thymocyte development is unknown. We have investigated the role by deleting the survivin gene only in the T lineage and show here that loss of survivin blocks the transition from CD4− CD8− double negative (DN) thy...

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Bibliographic Details
Main Authors: Okada, Hitoshi, Bakal, Chris, Shahinian, Arda, Elia, Andrew, Wakeham, Andrew, Suh, Woong-Kyung, Duncan, Gordon S., Ciofani, Maria, Rottapel, Robert, Zúñiga-Pflücker, Juan Carlos, Mak, Tak W.
Format: Online
Language:English
Published: The Rockefeller University Press 2004
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211792/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211792/

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