Autopathogenic T Helper Cell Type 1 (Th1) and Protective Th2 Clones Differ in Their Recognition of the Autoantigenic Peptide of Myelin Proteolipid Protein

Autopathogenic T Helper Cell Type 1 (Th1) and Protective Th2 Clones Differ in Their Recognition of the Autoantigenic Peptide of Myelin Proteolipid Protein

We previously generated a panel of T helper cell 1 (Th1) clones specific for an encephalitogenic peptide of myelin proteolipid protein (PLP) peptide 139–151 (HSLGKWLGHPDKF) that induces experimental autoimmune encephalomyelitis (EAE) upon adoptive transfer. In spite of the differences in their T cel...

Full description

Bibliographic Details
Main Authors:	Das, Mercy Prabhu, Nicholson, Lindsay B., Greer, Judith M., Kuchroo, Vijay K.
Format:	Online
Language:	English
Published:	The Rockefeller University Press 1997
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199041/

Similar Items

Autoimmune T-Cell Reactivity to Myelin Proteolipids and Glycolipids in Multiple Sclerosis
by: Greer, Judith M.
Published: (2013)

High Frequency of Autoreactive Myelin Proteolipid Protein–Specific T Cells in the Periphery of Naive Mice: Mechanisms of Selection of the Self-Reactive Repertoire
by: Anderson, Ana C., et al.
Published: (2000)

Helper activity for immunoglobulin synthesis of T helper type 1 (Th1) and Th2 human T cell clones: the help of Th1 clones is limited by their cytolytic capacity
Published: (1991)

NK-DC crosstalk controls the autopathogenic Th17 response through an innate IFN-γ–IL-27 axis
by: Chong, Wai Po, et al.
Published: (2015)

Overexpression of the myelin proteolipid protein leads to accumulation of cholesterol and proteolipid protein in endosomes/lysosomes: implications for Pelizaeus-Merzbacher disease
by: Simons, Mikael, et al.
Published: (2002)

Follicular Homing T Helper (Th) Cells and the Th1/Th2 Paradigm
by: Mackay, Charles R.
Published: (2000)

Specific inhibition of lymphokine biosynthesis and autocrine growth using antisense oligonucleotides in Th1 and Th2 helper T cell clones
Published: (1988)

Murine hepatic accessory cells support the proliferation of Th1 but not Th2 helper T lymphocyte clones
Published: (1989)

Assembly of Myelin by Association of Proteolipid Protein with Cholesterol- and Galactosylceramide-Rich Membrane Domains
by: Simons, Mikael, et al.
Published: (2000)

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones
Published: (1989)

YY1 negatively regulates mouse myelin proteolipid protein (Plp1) gene expression in oligodendroglial cells
by: Zolova, Olga E, et al.
Published: (2011)

Determinant Spreading of T Helper Cell 2 (Th2) Responses to Pancreatic Islet Autoantigens
by: Tian, Jide, et al.
Published: (1997)

Defining the functional states of Th17 cells
by: Lee, Youjin, et al.
Published: (2015)

A myelin proteolipid protein-LacZ fusion protein is developmentally regulated and targeted to the myelin membrane in transgenic mice
Published: (1993)

Immunomodulation and T Helper TH1/TH2 Response Polarization by CeO2 and TiO2 Nanoparticles
by: Schanen, Brian C., et al.
Published: (2013)

Mycobacterium tuberculosis TlyA Protein Negatively Regulates T Helper (Th) 1 and Th17 Differentiation and Promotes Tuberculosis Pathogenesis*
by: Rahman, Md. Aejazur, et al.
Published: (2015)

Oligonucleotide Adjuvants for T Helper 1 (Th1)–specific Vaccination
by: Carson, Dennis A., et al.
Published: (1997)

Distinct Role of Antigen-Specific T Helper Type 1 (Th1) and Th2 Cells in Tumor Eradication in Vivo
by: Nishimura, Takashi, et al.
Published: (1999)

Novel Genetic Regulation of T Helper 1 (Th1)/Th2 Cytokine Production and Encephalitogenicity in Inbred Mouse Strains
by: Conboy, Irina M., et al.
Published: (1997)

Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s
by: Bonecchi, Raffaella, et al.
Published: (1998)

Evidence for mouse Th1- and Th2-like helper T cells in vivo. Selective reduction of Th1-like cells after total lymphoid irradiation
Published: (1989)

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies
Published: (1987)

Protein Kinase C θ Is Critical for the Development of In Vivo T Helper (Th)2 Cell But Not Th1 Cell Responses
by: Marsland, Benjamin J., et al.
Published: (2004)

Selective Expression and Functions of Interleukin 18 Receptor on T Helper (Th) Type 1 but not Th2 Cells
by: Xu, Damo, et al.
Published: (1998)

Prevalence and Clinical Relevance of T-Helper Cells, Th17 and Th1, in Hepatitis B Virus-Related Hepatocellular Carcinoma
by: Yan, Jian, et al.
Published: (2014)

Skewed T-helper (Th)1/2- and Th17/T regulatory-cell balances in patients with renal cell carcinoma
by: LI, LONG, et al.
Published: (2015)

The initial events in myelin synthesis: orientation of proteolipid protein in the plasma membrane of cultured oligodendrocytes
Published: (1989)

Proteolipid protein–deficient myelin promotes axonal mitochondrial dysfunction via altered metabolic coupling
by: Yin, Xinghua, et al.
Published: (2016)

"Anergy" of TH0 helper T lymphocytes induces downregulation of TH1 characteristics and a transition to a TH2-like phenotype
Published: (1994)

Interleukin 21 Is a T Helper (Th) Cell 2 Cytokine that Specifically Inhibits the Differentiation of Naive Th Cells into Interferon γ–producing Th1 Cells
by: Wurster, Andrea L., et al.
Published: (2002)

Unequal Death in T Helper Cell (Th)1 and Th2 Effectors: Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis
by: Zhang, Xiaohong, et al.
Published: (1997)

Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23–Th17 pathway
by: Espinosa, Alexander, et al.
Published: (2009)

Role of Proteolipid Protein in HSV-1 Entry in Oligodendrocytic Cells
by: Bello-Morales, Raquel, et al.
Published: (2016)

Proteolipid protein 1 gene sequencing of hereditary spastic paraplegia☆
by: Gao, Yu, et al.
Published: (2012)

The atypical chemokine receptor ACKR2 suppresses Th17 responses to protein autoantigens
by: Hansell, Chris AH, et al.
Published: (2015)

Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells
by: Szabo, Susanne J., et al.
Published: (1997)

Inhibition of T1/St2 during Respiratory Syncytial Virus Infection Prevents T Helper Cell Type 2 (Th2)- but Not Th1-Driven Immunopathology
by: Walzl, Gerhard, et al.
Published: (2001)

T Helper 1 (Th1) and Th2 Characteristics Start to Develop During T Cell Priming and Are Associated with an Immediate Ability to Induce Immunoglobulin Class Switching
by: Toellner, Kai-Michael, et al.
Published: (1998)

Tissue Inhibitor of Metalloproteinase 1 Is Preferentially Expressed in Th1 and Th17 T-Helper Cell Subsets and Is a Direct Stat Target Gene
by: Adamson, Adewole, et al.
Published: (2013)

Ribavirin Exerts Differential Effects on Functions of Cd4+ Th1, Th2, and Regulatory T Cell Clones in Hepatitis C
by: Langhans, Bettina, et al.
Published: (2012)