Overexpression of the myelin proteolipid protein leads to accumulation of cholesterol and proteolipid protein in endosomes/lysosomes: implications for Pelizaeus-Merzbacher disease
Duplications and overexpression of the proteolipid protein (PLP) gene are known to cause the dysmyelinating disorder Pelizaeus-Merzbacher disease (PMD). To understand the cellular response to overexpressed PLP in PMD, we have overexpressed PLP in BHK cells and primary cultures of oligodendrocytes wi...
| Main Authors: | , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
2002
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199249/ |