Proteolipid protein–deficient myelin promotes axonal mitochondrial dysfunction via altered metabolic coupling

Proteolipid protein–deficient myelin promotes axonal mitochondrial dysfunction via altered metabolic coupling

The authors show that central nervous system myelin lacking proteolipid protein (PLP) induces mitochondrial dysfunction, including altered motility, degeneration, and ectopic smooth endoplasmic reticulum interactions, leading to axonal structural defects and degeneration. Mutated PLP occurs in hered...

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Bibliographic Details
Main Authors: Yin, Xinghua, Kidd, Grahame J., Ohno, Nobuhiko, Perkins, Guy A., Ellisman, Mark H., Bastian, Chinthasagar, Brunet, Sylvain, Baltan, Selva, Trapp, Bruce D.
Format: Online
Language:English
Published: The Rockefeller University Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119941/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119941/

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