T Cell Affinity Maturation by Selective Expansion during Infection
T lymphocyte recognition of infected cells is mediated by T cell receptors (TCRs) interacting with their ligands, self–major histocompatibility complex (MHC) molecules complexed with pathogen-derived peptides. Serial TCR interactions with potentially small numbers of MHC/ peptide complexes on infect...
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| Format: | Online |
| Language: | English |
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The Rockefeller University Press
1999
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192934/ |
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pubmed-2192934 |
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pubmed-21929342008-04-16 T Cell Affinity Maturation by Selective Expansion during Infection Busch, Dirk H. Pamer, Eric G. Articles T lymphocyte recognition of infected cells is mediated by T cell receptors (TCRs) interacting with their ligands, self–major histocompatibility complex (MHC) molecules complexed with pathogen-derived peptides. Serial TCR interactions with potentially small numbers of MHC/ peptide complexes on infected cells transmit signals that result in T lymphocyte expansion and activation of effector functions. The impact of TCR affinity for MHC/peptide complexes on the rate or extent of in vivo T cell expansion is not known. Here we show that in vivo expansion of complex T cell populations after bacterial infection is accompanied by an increase in their overall affinity for antigen. T cell populations that have undergone additional rounds of in vivo expansion express a narrower range of TCRs, have increased sensitivity for antigen in cytotoxic T lymphocyte assays, and bind MHC/peptide complexes with greater affinity. The selective expansion of higher affinity T cells provides an in vivo mechanism for optimizing the early detection of infected cells. The Rockefeller University Press 1999-02-15 /pmc/articles/PMC2192934/ /pubmed/9989985 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Busch, Dirk H. Pamer, Eric G. |
| spellingShingle |
Busch, Dirk H. Pamer, Eric G. T Cell Affinity Maturation by Selective Expansion during Infection |
| author_facet |
Busch, Dirk H. Pamer, Eric G. |
| author_sort |
Busch, Dirk H. |
| title |
T Cell Affinity Maturation by Selective Expansion during Infection |
| title_short |
T Cell Affinity Maturation by Selective Expansion during Infection |
| title_full |
T Cell Affinity Maturation by Selective Expansion during Infection |
| title_fullStr |
T Cell Affinity Maturation by Selective Expansion during Infection |
| title_full_unstemmed |
T Cell Affinity Maturation by Selective Expansion during Infection |
| title_sort |
t cell affinity maturation by selective expansion during infection |
| description |
T lymphocyte recognition of infected cells is mediated by T cell receptors (TCRs) interacting with their ligands, self–major histocompatibility complex (MHC) molecules complexed with pathogen-derived peptides. Serial TCR interactions with potentially small numbers of MHC/ peptide complexes on infected cells transmit signals that result in T lymphocyte expansion and activation of effector functions. The impact of TCR affinity for MHC/peptide complexes on the rate or extent of in vivo T cell expansion is not known. Here we show that in vivo expansion of complex T cell populations after bacterial infection is accompanied by an increase in their overall affinity for antigen. T cell populations that have undergone additional rounds of in vivo expansion express a narrower range of TCRs, have increased sensitivity for antigen in cytotoxic T lymphocyte assays, and bind MHC/peptide complexes with greater affinity. The selective expansion of higher affinity T cells provides an in vivo mechanism for optimizing the early detection of infected cells. |
| publisher |
The Rockefeller University Press |
| publishDate |
1999 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192934/ |
| _version_ |
1611430789354881024 |