Quantifying evolutionary constraints on B-cell affinity maturation
The antibody repertoire of each individual is continuously updated by the evolutionary process of B-cell receptor (BCR) mutation and selection. It has recently become possible to gain detailed information concerning this process through high-throughput sequencing. Here, we develop modern statistical...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The Royal Society
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528421/ |