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pubmed-2190519
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| recordtype |
oai_dc
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| spelling |
pubmed-21905192008-04-17 Tolerance to histocompatibility determinants in tetraparental bone marrow chimeras Articles Tetraparental bone marrow chimeras were produced by injecting lethally X-irradiated F1 hybrids with relatively high numbers of T-cell-depleted bone marrow cells from both allogeneic parental strains. The mice survival in excellent health and showed a stable, approximately 50:50 (parent:parent), lymphoid cell chimerism lasting for at least 7 mo after irradiation; regeneration of host-type hemopoietic cells was very limited. Thymus, lymph node, and thoracic duct lymphocytes showed specific unresponsiveness to host mixed leukocyte reaction (MLR) determinants. Similarly specific tolerance to H-2 antigens of host type was demonstrated in spleen and lymph node. No suppressor cells could be demonstrated in either system and blocking serum factors could not be found. The results suggest specific deletion of functional T cells reactive to host-type MLR and cell-mediated lympholysis determinants. The Rockefeller University Press 1975-02-01 /pmc/articles/PMC2190519/ /pubmed/46268 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
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| repository_type |
Open Access Journal
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| institution_category |
Foreign Institution
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| institution |
US National Center for Biotechnology Information
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| building |
NCBI PubMed
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| collection |
Online Access
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| language |
English
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| format |
Online
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| title |
Tolerance to histocompatibility determinants in tetraparental bone marrow chimeras
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| spellingShingle |
Tolerance to histocompatibility determinants in tetraparental bone marrow chimeras
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| title_short |
Tolerance to histocompatibility determinants in tetraparental bone marrow chimeras
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| title_full |
Tolerance to histocompatibility determinants in tetraparental bone marrow chimeras
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| title_fullStr |
Tolerance to histocompatibility determinants in tetraparental bone marrow chimeras
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| title_full_unstemmed |
Tolerance to histocompatibility determinants in tetraparental bone marrow chimeras
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| title_sort |
tolerance to histocompatibility determinants in tetraparental bone marrow chimeras
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| description |
Tetraparental bone marrow chimeras were produced by injecting lethally X-irradiated F1 hybrids with relatively high numbers of T-cell-depleted bone marrow cells from both allogeneic parental strains. The mice survival in excellent health and showed a stable, approximately 50:50 (parent:parent), lymphoid cell chimerism lasting for at least 7 mo after irradiation; regeneration of host-type hemopoietic cells was very limited. Thymus, lymph node, and thoracic duct lymphocytes showed specific unresponsiveness to host mixed leukocyte reaction (MLR) determinants. Similarly specific tolerance to H-2 antigens of host type was demonstrated in spleen and lymph node. No suppressor cells could be demonstrated in either system and blocking serum factors could not be found. The results suggest specific deletion of functional T cells reactive to host-type MLR and cell-mediated lympholysis determinants.
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| publisher |
The Rockefeller University Press
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| publishDate |
1975
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| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190519/
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| _version_ |
1611429369339707392
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