Strong T cell tolerance in parent----F1 bone marrow chimeras prepared with supralethal irradiation. Evidence for clonal deletion and anergy

T cell tolerance induction was examined in long-term H-2-heterozygous parent----F1 chimeras prepared with supralethal irradiation (1,300 rad). Although these chimeras appeared to be devoid of host-type APC, the donor T cells developing in the chimeras showed marked tolerance to host-type H-2 determi...

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Bibliographic Details
Format: Online
Language:English
Published: The Rockefeller University Press 1990
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187832/