T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis

T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis

This report shows that highly self-reactive T cells produced in mice as a result of genetically altered thymic T cell selection spontaneously differentiate into interleukin (IL)-17–secreting CD4+ helper T (Th) cells (Th17 cells), which mediate an autoimmune arthritis that clinically and immunologica...

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Bibliographic Details
Main Authors: Hirota, Keiji, Hashimoto, Motomu, Yoshitomi, Hiroyuki, Tanaka, Satoshi, Nomura, Takashi, Yamaguchi, Tomoyuki, Iwakura, Yoichiro, Sakaguchi, Noriko, Sakaguchi, Shimon
Format: Online
Language:English
Published: The Rockefeller University Press 2007
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118414/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118414/

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