Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells

T cell stimulation via glucocorticoid-induced tumor necrosis factor receptor family–related protein (GITR) can evoke effective tumor immunity. A single administration of agonistic anti-GITR monoclonal antibody (mAb) to tumor-bearing mice intravenously or directly into tumors provoked potent tumor-sp...

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Bibliographic Details
Main Authors: Ko, Kuibeom, Yamazaki, Sayuri, Nakamura, Kyoko, Nishioka, Tomohisa, Hirota, Keiji, Yamaguchi, Tomoyuki, Shimizu, Jun, Nomura, Takashi, Chiba, Tsutomu, Sakaguchi, Shimon
Format: Online
Language:English
Published: The Rockefeller University Press 2005
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213162/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213162/

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