Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation
B cells responding to T-dependent antigen either differentiate rapidly into extrafollicular plasma cells or enter germinal centers and undergo somatic hypermutation and affinity maturation. However, the physiological cues that direct B cell differentiation down one pathway versus the other are unkno...
| Main Authors: | , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
2006
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118299/ |