High affinity germinal center B cells are actively selected into the plasma cell compartment

A hallmark of T cell–dependent immune responses is the progressive increase in the ability of serum antibodies to bind antigen and provide immune protection. Affinity maturation of the antibody response is thought to be connected with the preferential survival of germinal centre (GC) B cells that ha...

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Bibliographic Details
Main Authors: Phan, Tri Giang, Paus, Didrik, Chan, Tyani D., Turner, Marian L., Nutt, Stephen L., Basten, Antony, Brink, Robert
Format: Online
Language:English
Published: The Rockefeller University Press 2006
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118125/