The Bcl10–Malt1 complex segregates FcɛRI-mediated nuclear factor κB activation and cytokine production from mast cell degranulation

The Bcl10–Malt1 complex segregates FcɛRI-mediated nuclear factor κB activation and cytokine production from mast cell degranulation

Mast cells are pivotal effector cells in IgE-mediated allergic inflammatory diseases. Central for mast cell activation are signals from the IgE receptor FcɛRI, which induce cell degranulation with the release of preformed mediators and de novo synthesis of proinflammatory leukotrienes and cytokines....

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Bibliographic Details
Main Authors: Klemm, Stefanie, Gutermuth, Jan, Hültner, Lothar, Sparwasser, Tim, Behrendt, Heidrun, Peschel, Christian, Mak, Tak W., Jakob, Thilo, Ruland, Jürgen
Format: Online
Language:English
Published: The Rockefeller University Press 2006
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118204/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118204/

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