Impaired degranulation but enhanced cytokine production after FcɛRI stimulation of diacylglycerol kinase ζ–deficient mast cells

Impaired degranulation but enhanced cytokine production after FcɛRI stimulation of diacylglycerol kinase ζ–deficient mast cells

Calcium and diacylglycerol are critical second messengers that together effect mast cell degranulation after allergen cross-linking of immunoglobulin (Ig)E-bound FcɛRI. Diacylglycerol kinase (DGK)ζ is a negative regulator of diacylglycerol-dependent signaling that acts by converting diacylglycerol t...

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Bibliographic Details
Main Authors: Olenchock, Benjamin A., Guo, Rishu, Silverman, Michael A., Wu, Jennifer N., Carpenter, Jeffery H., Koretzky, Gary A., Zhong, Xiao-Ping
Format: Online
Language:English
Published: The Rockefeller University Press 2006
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118304/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118304/

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