mdm2 gene mediates the expression of mdr1 gene and P-glycoprotein in a human glioblastoma cell line.
The overexpression of the multidrug resistance (mdr1) gene and its product, P-glycoprotein (P-gp), is thought to limit the successful chemotherapy of human tumours. The mechanism by which mdr1 gene and P-gp are overexpressed in human tumours, however, is not yet clear. In this report, we show that t...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Nature Publishing Group
1996
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2075914/ |