DT-diaphorase activity in normal and neoplastic human tissues; an indicator for sensitivity to bioreductive agents?
DT-diaphorase (DTD) is an important enzyme for the bioreductive activation of the new alkylating indoloquinone EO9. In preclinical studies, EO9 has shown selective anti-tumour activity against solid tumours and under hypoxic conditions. The levels of three reductive enzymes have been determined in t...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
1995
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034035/ |