6-Thioguanine: Antimitotic Effect on Human Lymphocytes in vitro Prevented by Adenine
The action of 6-thioguanine on the division of PHA-stimulated human lymphocytes in vitro has been investigated and shown to have a definite antimitotic effect which is prevented by adenine but not by guanine or hypoxanthine. It is suggested that in this test system 6-TG exerts its main inhibitory ac...
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| Format: | Online |
| Language: | English |
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1971
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008542/ |
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pubmed-2008542 |
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oai_dc |
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pubmed-20085422009-09-10 6-Thioguanine: Antimitotic Effect on Human Lymphocytes in vitro Prevented by Adenine Price, D. J. Timson, J. Articles The action of 6-thioguanine on the division of PHA-stimulated human lymphocytes in vitro has been investigated and shown to have a definite antimitotic effect which is prevented by adenine but not by guanine or hypoxanthine. It is suggested that in this test system 6-TG exerts its main inhibitory action on phosphoribosylpyrophosphate amidotransferase. 1971-03 /pmc/articles/PMC2008542/ /pubmed/5581289 Text en |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Price, D. J. Timson, J. |
| spellingShingle |
Price, D. J. Timson, J. 6-Thioguanine: Antimitotic Effect on Human Lymphocytes in vitro Prevented by Adenine |
| author_facet |
Price, D. J. Timson, J. |
| author_sort |
Price, D. J. |
| title |
6-Thioguanine: Antimitotic Effect on Human Lymphocytes in vitro Prevented by Adenine |
| title_short |
6-Thioguanine: Antimitotic Effect on Human Lymphocytes in vitro Prevented by Adenine |
| title_full |
6-Thioguanine: Antimitotic Effect on Human Lymphocytes in vitro Prevented by Adenine |
| title_fullStr |
6-Thioguanine: Antimitotic Effect on Human Lymphocytes in vitro Prevented by Adenine |
| title_full_unstemmed |
6-Thioguanine: Antimitotic Effect on Human Lymphocytes in vitro Prevented by Adenine |
| title_sort |
6-thioguanine: antimitotic effect on human lymphocytes in vitro prevented by adenine |
| description |
The action of 6-thioguanine on the division of PHA-stimulated human lymphocytes in vitro has been investigated and shown to have a definite antimitotic effect which is prevented by adenine but not by guanine or hypoxanthine. It is suggested that in this test system 6-TG exerts its main inhibitory action on phosphoribosylpyrophosphate amidotransferase. |
| publishDate |
1971 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008542/ |
| _version_ |
1611402629112397824 |