In vitro replication and thermodynamic studies of methylation and oxidation modifications of 6-thioguanine
The cytotoxic effects of thiopurine drugs are mostly exerted through the formation of thioguanine nucleotide and its subsequent incorporation into DNA. The 6-thioguanine (6-TG) in DNA can be converted to S6-methylthio-2-aminopurine (2-AP-6-SCH3) and 2-aminopurine-6-sulfonic acid (2-AP-6-SO3H) upon r...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
Oxford University Press
2007
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1920245/ |