Enhancement of the cytotoxicity of SR 4233 to normal and malignant tissues by hypoxic breathing.
The bioreductive cytotoxic agent SR 4233 (1,2,4-benzotriazine 3-amine 1,4-dioxide) has been shown to markedly potentiate the cell killing of mouse tumours when combined with fractionated radiation therapy. Differential metabolism under oxic compared to hypoxic conditions results in SR 4233 exhibitin...
| Main Authors: | , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
1992
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978042/ |