Molecular mechanisms of SR 4233-induced hepatocyte toxicity under aerobic versus hypoxic conditions.
SR 4233 (3-amino-1,2,4-benzotriazine-1,4-dioxide) is the lead compound of the benzotriazene-di-N oxides which are selectively toxic to tumour cells under hypoxic conditions. However much higher concentrations given to rats caused bone marrow toxicity and necrosis of the low oxygen Zone 3 part of the...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
1993
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968404/ |