The effect of pH on the aerobic and hypoxic cytotoxicity of SR4233 in HT-29 cells.
We have observed that low pH can substantially potentiate the cytotoxic effect of the bioreductive drug SR4233 in aerobic HT-29 human tumour cells. No such potentiation was observed under hypoxic conditions. This pH effect might be relevant both to the therapeutic effectiveness and to the normal tis...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
1993
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968590/ |