The pharmacokinetics of 5-fluorouracil administered by arterial infusion in advanced colorectal hepatic metastases.

The pharmacokinetics of 5-fluorouracil administered by arterial infusion in advanced colorectal hepatic metastases.

The pharmacokinetics of 5-fluorouracil (5FU) following its administration via the hepatic artery in conjunction with biodegradable albumin microspheres and angiotensin II have been studied. Peripheral venous concentrations of 5FU are lower and plasma clearance values higher following intrahepatic ar...

Full description

Bibliographic Details
Main Authors:	Goldberg, J. A., Kerr, D. J., Watson, D. G., Willmott, N., Bates, C. D., McKillop, J. H., McArdle, C. S.
Format:	Online
Language:	English
Published:	1990
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971687/

Similar Items

Pharmacokinetics and pharmacodynamics of locoregional 5 fluorouracil (5FU) in advanced colorectal liver metastases.
by: Goldberg, J. A., et al.
Published: (1988)

A phase II study of regional 5-fluorouracil infusion with intravenous folinic acid for colorectal liver metastases.
by: Warren, H. W., et al.
Published: (1994)

Arteriovenous shunting in patients with colorectal liver metastases.
by: Goldberg, J. A., et al.
Published: (1991)

The use of angiotensin II as a potential method of targeting cytotoxic microspheres in patients with intrahepatic tumour.
by: Goldberg, J. A., et al.
Published: (1991)

A phase II study of regional 2-weekly 5-fluorouracil infusion with intravenous folinic acid in the treatment of colorectal liver metastases.
by: Howell, J. D., et al.
Published: (1997)

A phase I study of regional 5-fluorouracil and systemic folinic acid for patients with colorectal liver metastases.
by: Anderson, J. H., et al.
Published: (1992)

Angiotensin II as a potential method of targeting cytotoxic-loaded microspheres in patients with colorectal liver metastases.
by: Goldberg, J. A., et al.
Published: (1991)

Pharmacokinetic study of 5-fluorouracil in a novel dialysate solution: a long-term intraperitoneal treatment approach for advanced colorectal carcinoma.
by: McArdle, C. S., et al.
Published: (1994)

Regional delivery of microspheres to liver metastases: the effects of particle size and concentration on intrahepatic distribution.
by: Anderson, J. H., et al.
Published: (1991)

An in vivo assessment of adriamycin-loaded albumin microspheres.
by: Goldberg, J. A., et al.
Published: (1992)

The use of duplex sonography in the detection of colorectal hepatic metastases.
by: Leen, E., et al.
Published: (1991)

Clinical correlation of high activity dynamic hepatic scintigraphy in patients with colorectal cancer.
by: Hemingway, D. M., et al.
Published: (1992)

A pharmacokinetic comparison of intravenous versus intra-arterial folinic acid.
by: Anderson, J. H., et al.
Published: (1992)

Regional chemotherapy for inoperable renal carcinoma: a method of targeting therapeutic microspheres to tumour.
by: Anderson, J. H., et al.
Published: (1991)

Is there a relationship between regional microsphere distribution and hepatic arterial blood flow?
by: Anderson, J. H., et al.
Published: (1992)

Monitoring blood flow to colorectal liver metastases using laser Doppler flowmetry: the effect of angiotensin II.
by: Hemingway, D. M., et al.
Published: (1992)

Prolonged intraperitoneal infusion of 5-fluorouracil using a novel carrier solution.
by: Kerr, D. J., et al.
Published: (1996)

Cigarette smoking among young adults: Integrating adolescent cognitive egocentrism with the trans-theoretical model.
by: Bright, Stephen, et al.
Published: (2008)

A phase I and pharmacokinetic study of didox administered by 36 hour infusion. The Cancer Research Campaign Phase I/II Clinical Trials Committee.
by: Carmichael, J., et al.
Published: (1990)

Pharmacokinetic rationale for the interaction of 5-fluorouracil and misonidazole in humans.
by: McDermott, B. J., et al.
Published: (1983)

The Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Relationships of Evacetrapib Administered as Monotherapy or in Combination With Statins
by: Friedrich, S, et al.
Published: (2014)

Efficacy and Safety of Hepatic Arterial Infusion of Fluorouracil with Leucovorin as Salvage Treatment for Refractory Liver Metastases from Colorectal Cancer
by: Lee, Hyun Jung, et al.
Published: (2011)

Letter: Blood levels of 5-fluorouracil during intravenous infusion.
by: Kawai, M., et al.
Published: (1976)

Duplex/colour Doppler sonography: measurement of changes in hepatic arterial haemodynamics following intra-arterial angiotensin II infusion.
by: Leen, E., et al.
Published: (1993)

Hepatic arterial chemotherapy for metastatic colorectal carcinoma.
by: de Takats, P. G., et al.
Published: (1994)

Mentoring school governance and management
by: Reynold J.S., Macpherson, et al.
Published: (2002)

Emerging Applications of Metabolomic and Genomic Profiling in Diabetic Clinical Medicine
by: McKillop, Aine M., et al.
Published: (2011)

A Broad Consideration of Risk Factors in Pediatric Chronic Pain: Where to Go from Here?
by: McKillop, Hannah N., et al.
Published: (2016)

Safety profile and pharmacokinetic analyses of the anti-CTLA4 antibody tremelimumab administered as a one hour infusion
by: Ribas, Antoni, et al.
Published: (2012)

Studies on the in vivo disposition of adriamycin in human tumours which exhibit different responses to the drug.
by: Cummings, J., et al.
Published: (1986)

Piperacillin/tazobactam administered by continuous or intermittent infusion for the treatment of nosocomial pneumonia
by: Lorente, L, et al.
Published: (2009)

The relation of ras family oncogene expression to conventional staging criteria and clinical outcome in colorectal carcinoma.
by: Kerr, I. B., et al.
Published: (1986)

Randomized Phase II Study of 5-Fluorouracil Hepatic Arterial Infusion with or without Antineoplastons as an Adjuvant Therapy after Hepatectomy for Liver Metastases from Colorectal Cancer
by: Ogata, Yutaka, et al.
Published: (2015)

High-dose folinic acid and 5-fluorouracil bolus and continuous infusion in advanced colorectal cancer: poor response rate in unselected patients.
by: Hanna, C. L., et al.
Published: (1995)

Cost Efficiency, Environmental Influences and UK Credit Unions, 1991 to 2001
by: Donal G., McKillop, et al.
Published: (2005)

Isolation and preliminary characterisation of cDNA clones representing mRNAs associated with tumour progression and metastasis in colorectal cancer.
by: Elvin, P., et al.
Published: (1988)

In vivo cell synchrony in the L1210 mouse leukaemia studied with 5-fluorouracil or 5-fluorouracil followed by cold thymidine infusion.
by: Camplejohn, R. S., et al.
Published: (1977)

The pharmacokinetics of orally administered butylscopolamine in greyhound dogs
by: Morris, Tim, et al.
Published: (2018)

The Role of Transporters in the Pharmacokinetics of Orally Administered Drugs
by: Shugarts, Sarah, et al.
Published: (2009)

Pharmacokinetics of doxorubicin co-administered with high-dose verapamil.
by: Gigante, M., et al.
Published: (1995)