How to quantify information loss due to phase ambiguity in haplotype case-control studies
Assigning haplotypes in a case-control study is a challenging problem. We proposed a method to quantify the information loss due to missing phase information. We determined which individuals were responsible for the information loss, and calculated how much information could be gained when the ambig...
Main Authors: | Uh, Hae-Won, Houwing-Duistermaat, Jeanine J, Putter, Hein, van Houwelingen, Hans C |
---|---|
Format: | Online |
Language: | English |
Published: |
BioMed Central
2005
|
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866831/ |
Similar Items
-
Modeling the effect of an associated single-nucleotide polymorphism in linkage studies
by: Houwing-Duistermaat, Jeanine J, et al.
Published: (2005) -
Does pathway analysis make it easier for common variants to tag rare ones?
by: Uh, Hae-Won, et al.
Published: (2011) -
Pathway analysis for family data using nested random-effects models
by: Houwing-Duistermaat, Jeanine J, et al.
Published: (2011) -
Combining evidence for association from transmission disequilibrium and case-control studies using single-nucleotide polymorphisms
by: Putter, Hein, et al.
Published: (2005) -
Combining information from linkage and association mapping for next-generation sequencing longitudinal family data
by: Balliu, Brunilda, et al.
Published: (2014)