Pathway analysis for family data using nested random-effects models

Recently we proposed a novel two-step approach to test for pathway effects in disease progression. The goal of this approach is to study the joint effect of multiple single-nucleotide polymorphisms that belong to certain genes. By using random effects, our approach acknowledges the correlations with...

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Bibliographic Details
Main Authors: Houwing-Duistermaat, Jeanine J, Uh, Hae-Won, Tsonaka, Roula
Format: Online
Language:English
Published: BioMed Central 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287857/