Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution

Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution

Human telomeric DNA consists of tandem repeats of the sequence d(TTAGGG). The formation and stabilization of DNA G-quadruplexes in the human telomeric sequence have been shown to inhibit the activity of telomerase, thus the telomeric DNA G-quadruplex has been considered as an attractive target for c...

Full description

Bibliographic Details
Main Authors:	Ambrus, Attila, Chen, Ding, Dai, Jixun, Bialis, Tiffanie, Jones, Roger A., Yang, Danzhou
Format:	Online
Language:	English
Published:	Oxford University Press 2006
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1464114/

Similar Items

Structure of the intramolecular human telomeric G-quadruplex in potassium solution: a novel adenine triple formation
by: Dai, Jixun, et al.
Published: (2007)

Structure of the Hybrid-2 type intramolecular human telomeric G-quadruplex in K+ solution: insights into structure polymorphism of the human telomeric sequence
by: Dai, Jixun, et al.
Published: (2007)

c-MYC promoter G-quadruplex formed at the 5′-end of NHE III1 element: insights into biological relevance and parallel-stranded G-quadruplex stability
by: Mathad, Raveendra I., et al.
Published: (2011)

Conformation and Stability of Intramolecular Telomeric G-Quadruplexes: Sequence Effects in the Loops
by: Sattin, Giovanna, et al.
Published: (2013)

Structure of the human telomere in Na+ solution: an antiparallel (2+2) G-quadruplex scaffold reveals additional diversity
by: Lim, Kah Wai, et al.
Published: (2013)

Formation and stabilization of the telomeric antiparallel G-quadruplex and inhibition of telomerase by novel benzothioxanthene derivatives with anti-tumor activity
by: Zhang, Wen, et al.
Published: (2015)

General Cell-Binding Activity of Intramolecular G-Quadruplexes with Parallel Structure
by: Chang, Tianjun, et al.
Published: (2013)

NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region
by: Dai, Jixun, et al.
Published: (2006)

An Intramolecular G-Quadruplex Structure Is Required for Binding of Telomeric Repeat-Containing RNA to the Telomeric Protein TRF2
by: Biffi, Giulia, et al.
Published: (2012)

Solution structure of the major G-quadruplex formed in the human VEGF promoter in K+: insights into loop interactions of the parallel G-quadruplexes
by: Agrawal, Prashansa, et al.
Published: (2013)

Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution†
by: Phan, Anh Tuân, et al.
Published: (2007)

Different loop arrangements of intramolecular human telomeric (3+1) G-quadruplexes in K+ solution
by: Phan, Anh Tuân, et al.
Published: (2006)

Intramolecular Telomeric G-Quadruplexes Dramatically Inhibit DNA Synthesis by Replicative and Translesion Polymerases, Revealing their Potential to Lead to Genetic Change
by: Edwards, Deanna N., et al.
Published: (2014)

Stability of telomeric G-quadruplexes
by: Tran, Phong Lan Thao, et al.
Published: (2011)

G-quadruplex formation in human telomeric (TTAGGG)4 sequence with complementary strand in close vicinity under molecularly crowded condition
by: Kan, Zhong-yuan, et al.
Published: (2007)

Intramolecular DNA quadruplexes with different arrangements of short and long loops
by: Rachwal, Phillip A., et al.
Published: (2007)

Solution-state structure of an intramolecular G-quadruplex with propeller, diagonal and edgewise loops
by: Marušič, Maja, et al.
Published: (2012)

Structural Studies on Dinuclear Ruthenium(II) Complexes That Bind Diastereoselectively to an Antiparallel Folded Human Telomere Sequence
by: Wilson, Tom, et al.
Published: (2013)

DNA polymerase δ stalls on telomeric lagging strand templates independently from G-quadruplex formation
by: Lormand, Justin D., et al.
Published: (2013)

Covalent ligation studies on the human telomere quadruplex
by: Qi, Jianying, et al.
Published: (2005)

Vertebrate telomere repeat DNAs favor external loop propeller quadruplex structures in the presence of high concentrations of potassium
by: Rujan, Iulian N., et al.
Published: (2005)

Structural basis of sodium–potassium exchange of a human telomeric DNA quadruplex without topological conversion
by: Wang, Zi-Fu, et al.
Published: (2014)

Selective recognition and stabilization of new ligands targeting the potassium form of the human telomeric G-quadruplex DNA
by: Lin, Yi-Hwa, et al.
Published: (2016)

The exception that confirms the rule: a higher-order telomeric G-quadruplex structure more stable in sodium than in potassium
by: Saintomé, Carole, et al.
Published: (2016)

Molecular dynamics and principal components of potassium binding with human telomeric intra-molecular G-quadruplex
by: Wang, Zhiguo, et al.
Published: (2015)

Recognition and Binding of Human Telomeric G-Quadruplex DNA by Unfolding Protein 1
by: Hudson, Jason S., et al.
Published: (2014)

The parallel G-quadruplex structure of vertebrate telomeric repeat sequences is not the preferred folding topology under physiological conditions
by: Hänsel, Robert, et al.
Published: (2011)

Monoclonal antibodies binding to the tail of Dictyostelium discoideum myosin: their effects on antiparallel and parallel assembly and actin- activated ATPase activity
Published: (1986)

Polarity of dynein-microtubule interactions in vitro: cross-bridging between parallel and antiparallel microtubules
Published: (1981)

Structural Aspects of the Antiparallel and Parallel Duplexes Formed by DNA, 2’-O-Methyl RNA and RNA Oligonucleotides
by: Szabat, Marta, et al.
Published: (2015)

The Major G-Quadruplex Formed in the Human BCL-2 Proximal Promoter Adopts a Parallel Structure with a 13-nt Loop in K+ Solution
by: Agrawal, Prashansa, et al.
Published: (2014)

BLM helicase facilitates telomere replication during leading strand synthesis of telomeres
by: Drosopoulos, William C., et al.
Published: (2015)

Modelling the regulation of telomere length: the effects of telomerase and G-quadruplex stabilising drugs
by: Hirt, Bartholomäus V., et al.
Published: (2014)

Natural isoflavones regulate the quadruplex–duplex competition in human telomeric DNA
by: Zhang, Jin-li, et al.
Published: (2011)

Disordering of Human Telomeric G-Quadruplex with Novel Antiproliferative Anthrathiophenedione
by: Kaluzhny, Dmitry, et al.
Published: (2011)

Put on your thinking cap: G-quadruplexes, helicases, and telomeres
by: Brosh, Robert M.
Published: (2011)

Human replication protein A unfolds telomeric G-quadruplexes
by: Salas, Tonatiuh Romero, et al.
Published: (2006)

Kinetic Partitioning Modulates Human Telomere DNA G-Quadruplex Structural Polymorphism
by: Long, Xi, et al.
Published: (2013)

Modelling the regulation of telomere length: the effects of telomerase and G-quadruplex stabilising drugs
by: Hirt, Bartholomäus V., et al.
Published: (2013)

G-Quadruplex binding enantiomers show chiral selective interactions with human telomere
by: Wang, Jiasi, et al.
Published: (2014)