Modelling the regulation of telomere length: the effects of telomerase and G-quadruplex stabilising drugs
Telomeres are guanine-rich sequences at the end of chromosomes which shorten during each replication event and trigger cell cycle arrest and/or controlled death (apoptosis) when reaching a threshold length. The enzyme telomerase replenishes the ends of telomeres and thus prolongs the life span of ce...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer
2014
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| Online Access: | http://eprints.nottingham.ac.uk/3036/ http://eprints.nottingham.ac.uk/3036/ http://eprints.nottingham.ac.uk/3036/ http://eprints.nottingham.ac.uk/3036/1/art%253A10.1007%252Fs00285-013-0678-2.pdf |