Tubulin inhibitors targeting the colchicine binding site: a perspective of privileged structures

The vital roles of microtubule in mitosis and cell division make it an attractive target for antitumor therapy. Colchicine binding site of tubulin is one of the most important pockets that have been focused on to design tubulin-destabilizing agents. Over the past few years, a large number of colchic...

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Main Authors:	Li, Wenlong, Sun, Honghao, Xu, Shengtao, Zhu, Zheying, Xu, Jinyi
Format:	Article
Language:	English
Published:	Future Science 2017
Online Access:	http://eprints.nottingham.ac.uk/46454/ http://eprints.nottingham.ac.uk/46454/ http://eprints.nottingham.ac.uk/46454/ http://eprints.nottingham.ac.uk/46454/1/FMC-2017-0100-accepted.pdf

id	nottingham-46454
recordtype	eprints
spelling	nottingham-464542017-11-07T02:14:15Z http://eprints.nottingham.ac.uk/46454/ Tubulin inhibitors targeting the colchicine binding site: a perspective of privileged structures Li, Wenlong Sun, Honghao Xu, Shengtao Zhu, Zheying Xu, Jinyi The vital roles of microtubule in mitosis and cell division make it an attractive target for antitumor therapy. Colchicine binding site of tubulin is one of the most important pockets that have been focused on to design tubulin-destabilizing agents. Over the past few years, a large number of colchicine binding site inhibitors (CBSIs) have been developed inspired by natural products or synthetic origins, and many moieties frequently used in these CBSIs are structurally in common. In this review, we will classify the CBSIs into classical CBSIs and nonclassical CBSIs according to their spatial conformations and binding modes with tubulin, and highlight the privileged structures from these CBSIs in the development of tubulin inhibitors targeting the colchicine binding site. Future Science 2017-09-20 Article PeerReviewed application/pdf en http://eprints.nottingham.ac.uk/46454/1/FMC-2017-0100-accepted.pdf Li, Wenlong and Sun, Honghao and Xu, Shengtao and Zhu, Zheying and Xu, Jinyi (2017) Tubulin inhibitors targeting the colchicine binding site: a perspective of privileged structures. Future Medicinal Chemistry, 9 (15). ISSN 1756-8927 https://www.future-science.com/doi/10.4155/fmc-2017-0100 doi:10.4155/fmc-2017-0100 doi:10.4155/fmc-2017-0100
repository_type	Digital Repository
institution_category	Local University
institution	University of Nottingham Malaysia Campus
building	Nottingham Research Data Repository
collection	Online Access
language	English
description	The vital roles of microtubule in mitosis and cell division make it an attractive target for antitumor therapy. Colchicine binding site of tubulin is one of the most important pockets that have been focused on to design tubulin-destabilizing agents. Over the past few years, a large number of colchicine binding site inhibitors (CBSIs) have been developed inspired by natural products or synthetic origins, and many moieties frequently used in these CBSIs are structurally in common. In this review, we will classify the CBSIs into classical CBSIs and nonclassical CBSIs according to their spatial conformations and binding modes with tubulin, and highlight the privileged structures from these CBSIs in the development of tubulin inhibitors targeting the colchicine binding site.
format	Article
author	Li, Wenlong Sun, Honghao Xu, Shengtao Zhu, Zheying Xu, Jinyi
spellingShingle	Li, Wenlong Sun, Honghao Xu, Shengtao Zhu, Zheying Xu, Jinyi Tubulin inhibitors targeting the colchicine binding site: a perspective of privileged structures
author_facet	Li, Wenlong Sun, Honghao Xu, Shengtao Zhu, Zheying Xu, Jinyi
author_sort	Li, Wenlong
title	Tubulin inhibitors targeting the colchicine binding site: a perspective of privileged structures
title_short	Tubulin inhibitors targeting the colchicine binding site: a perspective of privileged structures
title_full	Tubulin inhibitors targeting the colchicine binding site: a perspective of privileged structures
title_fullStr	Tubulin inhibitors targeting the colchicine binding site: a perspective of privileged structures
title_full_unstemmed	Tubulin inhibitors targeting the colchicine binding site: a perspective of privileged structures
title_sort	tubulin inhibitors targeting the colchicine binding site: a perspective of privileged structures
publisher	Future Science
publishDate	2017
url	http://eprints.nottingham.ac.uk/46454/ http://eprints.nottingham.ac.uk/46454/ http://eprints.nottingham.ac.uk/46454/ http://eprints.nottingham.ac.uk/46454/1/FMC-2017-0100-accepted.pdf
first_indexed	2018-09-06T13:46:48Z
last_indexed	2018-09-06T13:46:48Z
_version_	1610866081454358528

Tubulin inhibitors targeting the colchicine binding site: a perspective of privileged structures

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