Crystal Structure of Enhanced Green Fluorescent Protein to 1.35 Å Resolution Reveals Alternative Conformations for Glu222

by Arpino, James A. J., Rizkallah, Pierre J., Jones, D. Dafydd
Published 2012

Structural and dynamic changes associated with beneficial engineered single-amino-acid deletion mutations in enhanced green fluorescent protein

by Arpino, James A. J., Rizkallah, Pierre J., Jones, D. Dafydd
Published 2014

Random Single Amino Acid Deletion Sampling Unveils Structural Tolerance and the Benefits of Helical Registry Shift on GFP Folding and Structure

by Arpino, James A.J., Reddington, Samuel C., Halliwell, Lisa M., Rizkallah, Pierre J., Jones, D. Dafydd
Published 2014

TCR/pMHC Optimized Protein crystallization Screen

by Bulek, Anna M., Madura, Florian, Fuller, Anna, Holland, Christopher J., Schauenburg, Andrea J.A., Sewell, Andrew K., Rizkallah, Pierre J., Cole, David K.
Published 2012

Minimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimers

by Holland, Christopher J., Rizkallah, Pierre J., Vollers, Sabrina, Calvo-Calle, J. Mauricio, Madura, Florian, Fuller, Anna, Sewell, Andrew K., Stern, Lawrence J., Godkin, Andrew, Cole, David K.
Published 2012

Molecular Basis of a Dominant T Cell Response to an HIV Reverse Transcriptase 8-mer Epitope Presented by the Protective Allele HLA-B*51:01

by Motozono, Chihiro, Kuse, Nozomi, Sun, Xiaoming, Rizkallah, Pierre J., Fuller, Anna, Oka, Shinichi, Cole, David K., Sewell, Andrew K., Takiguchi, Masafumi
Published 2014

Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide*

by Motozono, Chihiro, Pearson, James A., De Leenheer, Evy, Rizkallah, Pierre J., Beck, Konrad, Trimby, Andrew, Sewell, Andrew K., Wong, F. Susan, Cole, David K.
Published 2015

A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen*

by Bianchi, Valentina, Bulek, Anna, Fuller, Anna, Lloyd, Angharad, Attaf, Meriem, Rizkallah, Pierre J., Dolton, Garry, Sewell, Andrew K., Cole, David K.
Published 2016

Structural basis for ineffective T-cell responses to MHC anchor residue-improved “heteroclitic” peptides

by Madura, Florian, Rizkallah, Pierre J, Holland, Christopher J, Fuller, Anna, Bulek, Anna, Godkin, Andrew J, Schauenburg, Andrea J, Cole, David K, Sewell, Andrew K
Published 2015

A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape

by Kløverpris, Henrik N, Cole, David K, Fuller, Anna, Carlson, Jonathan, Beck, Konrad, Schauenburg, Andrea J, Rizkallah, Pierre J, Buus, Søren, Sewell, Andrew K, Goulder, Philip
Published 2015

Increased Peptide Contacts Govern High Affinity Binding of a Modified TCR Whilst Maintaining a Native pMHC Docking Mode

by Cole, David K., Sami, Malkit, Scott, Daniel R., Rizkallah, Pierre J., Borbulevych, Oleg Y., Todorov, Penio T., Moysey, Ruth K., Jakobsen, Bent K., Boulter, Jonathan M., Baker, Brian M., Yi Li
Published 2013

Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy

by Raman, Marine C C, Rizkallah, Pierre J, Simmons, Ruth, Donnellan, Zoe, Dukes, Joseph, Bossi, Giovanna, Le Provost, Gabrielle S, Todorov, Penio, Baston, Emma, Hickman, Emma, Mahon, Tara, Hassan, Namir, Vuidepot, Annelise, Sami, Malkit, Cole, David K, Jakobsen, Bent K.
Published 2016

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

by Cole, David K., Bulek, Anna M., Dolton, Garry, Schauenberg, Andrea J., Szomolay, Barbara, Rittase, William, Trimby, Andrew, Jothikumar, Prithiviraj, Fuller, Anna, Skowera, Ania, Rossjohn, Jamie, Zhu, Cheng, Miles, John J., Peakman, Mark, Wooldridge, Linda, Rizkallah, Pierre J., Sewell, Andrew K.
Published 2016

Structural basis of human β-cell killing by CD8+ T cells in Type 1 diabetes

by Bulek, Anna M., Cole, David K., Skowera, Ania, Dolton, Garry, Gras, Stephanie, Madura, Florian, Fuller, Anna, Miles, John J., Gostick, Emma, Price, David A., Drijfhout, Jan W., Knight, Robin R., Huang, Guo C., Lissin, Nikolai, Molloy, Peter E., Wooldridge, Linda, Jakobsen, Bent K., Rossjohn, Jamie, Peakman, Mark, Rizkallah, Pierre J., Sewell, Andrew K.
Published 2012

T-cell Receptor-optimized Peptide Skewing of the T-cell Repertoire Can Enhance Antigen Targeting*

by Ekeruche-Makinde, Julia, Clement, Mathew, Cole, David K., Edwards, Emily S. J., Ladell, Kristin, Miles, John J., Matthews, Katherine K., Fuller, Anna, Lloyd, Katy A., Madura, Florian, Dolton, Garry M., Pentier, Johanne, Lissina, Anna, Gostick, Emma, Baxter, Tiffany K., Baker, Brian M., Rizkallah, Pierre J., Price, David A., Wooldridge, Linda, Sewell, Andrew K.
Published 2012

T-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex Interactions*

by Cole, David K., Miles, Kim M., Madura, Florian, Holland, Christopher J., Schauenburg, Andrea J. A., Godkin, Andrew J., Bulek, Anna M., Fuller, Anna, Akpovwa, Hephzibah J. E., Pymm, Phillip G., Liddy, Nathaniel, Sami, Malkit, Li, Yi, Rizkallah, Pierre J., Jakobsen, Bent K., Sewell, Andrew K.
Published 2014

T-cell Receptor Specificity Maintained by Altered Thermodynamics*

by Madura, Florian, Rizkallah, Pierre J., Miles, Kim M., Holland, Christopher J., Bulek, Anna M., Fuller, Anna, Schauenburg, Andrea J. A., Miles, John J., Liddy, Nathaniel, Sami, Malkit, Li, Yi, Hossain, Moushumi, Baker, Brian M., Jakobsen, Bent K., Sewell, Andrew K., Cole, David K.
Published 2013