Increased Peptide Contacts Govern High Affinity Binding of a Modified TCR Whilst Maintaining a Native pMHC Docking Mode

by Cole, David K., Sami, Malkit, Scott, Daniel R., Rizkallah, Pierre J., Borbulevych, Oleg Y., Todorov, Penio T., Moysey, Ruth K., Jakobsen, Bent K., Boulter, Jonathan M., Baker, Brian M., Yi Li
Published 2013

ImmTACs: bi-specific TCR-anti-CD3 fusions for targeted tumour killing

by Donnellan, Zoe, Bossi, Giovanna, Harper, Jane, Dukes, Joseph, Liddy, Nathaniel, Paston, Samantha, Mahon, Tara, Molloy, Peter, Sami, Malkit, Baston, Emma, Cameron, Brian, Johnson, Andrew, Vuidepot, Annelise, Hassan, Namir, Jakobsen, Bent
Published 2015

Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy

by Raman, Marine C C, Rizkallah, Pierre J, Simmons, Ruth, Donnellan, Zoe, Dukes, Joseph, Bossi, Giovanna, Le Provost, Gabrielle S, Todorov, Penio, Baston, Emma, Hickman, Emma, Mahon, Tara, Hassan, Namir, Vuidepot, Annelise, Sami, Malkit, Cole, David K, Jakobsen, Bent K.
Published 2016

Structural and kinetic basis for heightened immunogenicity of T cell vaccines

by Chen, Ji-Li, Stewart-Jones, Guillaume, Bossi, Giovanna, Lissin, Nikolai M., Wooldridge, Linda, Choi, Ed Man Lik, Held, Gerhard, Dunbar, P. Rod, Esnouf, Robert M., Sami, Malkit, Boulter, Jonathan M., Rizkallah, Pierre, Renner, Christoph, Sewell, Andrew, van der Merwe, P. Anton, Jakobsen, Bent K., Griffiths, Gillian, Jones, E. Yvonne, Cerundolo, Vincenzo
Published 2005

Bi-specific TCR-anti CD3 redirected T-cell targeting of NY-ESO-1- and LAGE-1-positive tumors

by McCormack, Emmet, Adams, Katherine J., Hassan, Namir J., Kotian, Akhil, Lissin, Nikolai M., Sami, Malkit, Mujić, Maja, Osdal, Tereza, Gjertsen, Bjørn Tore, Baker, Deborah, Powlesland, Alex S., Aleksic, Milos, Vuidepot, Annelise, Morteau, Olivier, Sutton, Deborah H., June, Carl H., Kalos, Michael, Ashfield, Rebecca, Jakobsen, Bent K.
Published 2012

T-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex Interactions*

by Cole, David K., Miles, Kim M., Madura, Florian, Holland, Christopher J., Schauenburg, Andrea J. A., Godkin, Andrew J., Bulek, Anna M., Fuller, Anna, Akpovwa, Hephzibah J. E., Pymm, Phillip G., Liddy, Nathaniel, Sami, Malkit, Li, Yi, Rizkallah, Pierre J., Jakobsen, Bent K., Sewell, Andrew K.
Published 2014

T-cell Receptor Specificity Maintained by Altered Thermodynamics*

by Madura, Florian, Rizkallah, Pierre J., Miles, Kim M., Holland, Christopher J., Bulek, Anna M., Fuller, Anna, Schauenburg, Andrea J. A., Miles, John J., Liddy, Nathaniel, Sami, Malkit, Li, Yi, Hossain, Moushumi, Baker, Brian M., Jakobsen, Bent K., Sewell, Andrew K., Cole, David K.
Published 2013