Genetic Risk Score Predicting Risk of Rheumatoid Arthritis Phenotypes and Age of Symptom Onset

by Chibnik, Lori B., Keenan, Brendan T., Cui, Jing, Liao, Katherine P., Costenbader, Karen H., Plenge, Robert M., Karlson, Elizabeth W.
Published 2011

The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1

by Li, Gang, Cunin, Pierre, Wu, Di, Diogo, Dorothée, Yang, Yu, Okada, Yukinori, Plenge, Robert M., Nigrovic, Peter A.
Published 2016

Defining the Role of the MHC in Autoimmunity: A Review and Pooled Analysis

by Fernando, Michelle M. A., Stevens, Christine R., Walsh, Emily C., De Jager, Philip L., Goyette, Philippe, Plenge, Robert M., Vyse, Timothy J., Rioux, John D.
Published 2008

Analysis and Application of European Genetic Substructure Using 300 K SNP Information

by Tian, Chao, Plenge, Robert M, Ransom, Michael, Lee, Annette, Villoslada, Pablo, Selmi, Carlo, Klareskog, Lars, Pulver, Ann E, Qi, Lihong, Gregersen, Peter K, Seldin, Michael F
Published 2008

Identification of the NF-κB activating protein-like locus as a risk locus for rheumatoid arthritis

by Xie, Gang, Lu, Yue, Sun, Ye, Zhang, Steven Shiyang, Keystone, Edward Clark, Gregersen, Peter K, Plenge, Robert M, Amos, Christopher I, Siminovitch, Katherine A
Published 2013

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis

by Raychaudhuri, Soumya, Sandor, Cynthia, Stahl, Eli A., Freudenberg, Jan, Lee, Hye-Soon, Jia, Xiaoming, Alfredsson, Lars, Padyukov, Leonid, Klareskog, Lars, Worthington, Jane, Siminovitch, Katherine A., Bae, Sang-Cheol, Plenge, Robert M., Gregersen, Peter K., de Bakker, Paul I.W.
Published 2012

Automatic Prediction of Rheumatoid Arthritis Disease Activity from the Electronic Medical Records

by Lin, Chen, Karlson, Elizabeth W., Canhao, Helena, Miller, Timothy A., Dligach, Dmitriy, Chen, Pei Jun, Perez, Raul Natanael Guzman, Shen, Yuanyan, Weinblatt, Michael E., Shadick, Nancy A., Plenge, Robert M., Savova, Guergana K.
Published 2013

Quantifying Missing Heritability at Known GWAS Loci

by Gusev, Alexander, Bhatia, Gaurav, Zaitlen, Noah, Vilhjalmsson, Bjarni J., Diogo, Dorothée, Stahl, Eli A., Gregersen, Peter K., Worthington, Jane, Klareskog, Lars, Raychaudhuri, Soumya, Plenge, Robert M., Pasaniuc, Bogdan, Price, Alkes L.
Published 2013

The Influence of Polygenic Risk Scores on Heritability of Anti-CCP Level in RA

by Cui, Jing, Taylor, Kimberly E., Lee, Yvonne C., Källberg, Henrik, Weinblatt, Michael E., Coblyn, Jonathan S., Klareskog, Lars, Criswell, Lindsey A., Gregersen, Peter K., Shadick, Nancy A., Plenge, Robert M., Karlson, Elizabeth W.
Published 2014

Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction

by Klarenbeek, Paul L., Doorenspleet, Marieke E., Esveldt, Rebecca E. E., van Schaik, Barbera D. C., Lardy, Neubury, van Kampen, Antoine H. C., Tak, Paul P., Plenge, Robert M., Baas, Frank, de Bakker, Paul I. W., de Vries, Niek
Published 2015

Human Genetics in Rheumatoid Arthritis Guides a High-Throughput Drug Screen of the CD40 Signaling Pathway

by Li, Gang, Diogo, Dorothée, Wu, Di, Spoonamore, Jim, Dancik, Vlado, Franke, Lude, Kurreeman, Fina, Rossin, Elizabeth J., Duclos, Grant, Hartland, Cathy, Zhou, Xuezhong, Li, Kejie, Liu, Jun, De Jager, Philip L., Siminovitch, Katherine A., Zhernakova, Alexandra, Raychaudhuri, Soumya, Bowes, John, Eyre, Steve, Padyukov, Leonid, Gregersen, Peter K., Worthington, Jane, Gupta, Namrata, Clemons, Paul A., Stahl, Eli, Tolliday, Nicola, Plenge, Robert M.
Published 2013

Modeling Disease Severity in Multiple Sclerosis Using Electronic Health Records

by Xia, Zongqi, Secor, Elizabeth, Chibnik, Lori B., Bove, Riley M., Cheng, Suchun, Chitnis, Tanuja, Cagan, Andrew, Gainer, Vivian S., Chen, Pei J., Liao, Katherine P., Shaw, Stanley Y., Ananthakrishnan, Ashwin N., Szolovits, Peter, Weiner, Howard L., Karlson, Elizabeth W., Murphy, Shawn N., Savova, Guergana K., Cai, Tianxi, Churchill, Susanne E., Plenge, Robert M., Kohane, Isaac S., De Jager, Philip L.
Published 2013

Methods to Develop an Electronic Medical Record Phenotype Algorithm to Compare the Risk of Coronary Artery Disease across 3 Chronic Disease Cohorts

by Liao, Katherine P., Ananthakrishnan, Ashwin N., Kumar, Vishesh, Xia, Zongqi, Cagan, Andrew, Gainer, Vivian S., Goryachev, Sergey, Chen, Pei, Savova, Guergana K., Agniel, Denis, Churchill, Susanne, Lee, Jaeyoung, Murphy, Shawn N., Plenge, Robert M., Szolovits, Peter, Kohane, Isaac, Shaw, Stanley Y., Karlson, Elizabeth W., Cai, Tianxi
Published 2015

Polygenic Inheritance of Paclitaxel-Induced Sensory Peripheral Neuropathy Driven by Axon Outgrowth Gene Sets in CALGB 40101 (Alliance)

by Chhibber, Aparna, Mefford, Joel, Stahl, Eli A., Pendergrass, Sarah A., Baldwin, R. Michael, Owzar, Kouros, Li, Megan, Winer, Eric P., Hudis, Clifford A., Zembutsu, Hitoshi, Kubo, Michiaki, Nakamura, Yusuke, McLeod, Howard L., Ratain, Mark J., Shulman, Lawrence N., Ritchie, Marylyn D., Plenge, Robert M., Witte, John S., Kroetz, Deanna L.
Published 2014

Crowdsourcing genetic prediction of clinical utility in the Rheumatoid Arthritis Responder Challenge

by Plenge, Robert M., Greenberg, Jeffrey D., Mangravite, Lara M., Derry, Jonathan M. J., Stahl, Eli A., Coenen, Marieke J. H., Barton, Anne, Padyukov, Leonid, Klareskog, Lars, Gregersen, Peter K., Mariette, Xavier, Moreland, Larry W., Bridges, S Louis, de Vries, Niek, Huizinga, Tom W. J., Guchelaar, Henk-Jan, Friend, Stephen H., Stolovitzky, Gustavo
Published 2013

TRAF1/C5 but Not PTPRC Variants Are Potential Predictors of Rheumatoid Arthritis Response to Anti-Tumor Necrosis Factor Therapy

by Canhão, Helena, Rodrigues, Ana Maria, Santos, Maria José, Carmona-Fernandes, Diana, Bettencourt, Bruno F., Cui, Jing, Rocha, Fabiana L., Canas Silva, José, Polido-Pereira, Joaquim, Pereira Silva, José Alberto, Costa, José António, Araujo, Domingos, Silva, Cândida, Santos, Helena, Duarte, Cátia, Cáliz, Rafael, Filipescu, Ileana, Pimentel-Santos, Fernando, Branco, Jaime, Sainz, Juan, Plenge, Robert M., Solomon, Daniel H., Bruges-Armas, Jácome, Da Silva, José António P., Fonseca, João Eurico, Karlson, Elizabeth W.
Published 2015

Informed Conditioning on Clinical Covariates Increases Power in Case-Control Association Studies

by Zaitlen, Noah, Lindström, Sara, Pasaniuc, Bogdan, Cornelis, Marilyn, Genovese, Giulio, Pollack, Samuela, Barton, Anne, Bickeböller, Heike, Bowden, Donald W., Eyre, Steve, Freedman, Barry I., Friedman, David J., Field, John K., Groop, Leif, Haugen, Aage, Heinrich, Joachim, Henderson, Brian E., Hicks, Pamela J., Hocking, Lynne J., Kolonel, Laurence N., Landi, Maria Teresa, Langefeld, Carl D., Le Marchand, Loic, Meister, Michael, Morgan, Ann W., Raji, Olaide Y., Risch, Angela, Rosenberger, Albert, Scherf, David, Steer, Sophia, Walshaw, Martin, Waters, Kevin M., Wilson, Anthony G., Wordsworth, Paul, Zienolddiny, Shanbeh, Tchetgen, Eric Tchetgen, Haiman, Christopher, Hunter, David J., Plenge, Robert M., Worthington, Jane, Christiani, David C., Schaumberg, Debra A., Chasman, Daniel I., Altshuler, David, Voight, Benjamin, Kraft, Peter, Patterson, Nick, Price, Alkes L.
Published 2012

Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis

by Cui, Jing, Stahl, Eli A., Saevarsdottir, Saedis, Miceli, Corinne, Diogo, Dorothee, Trynka, Gosia, Raj, Towfique, Mirkov, Maša Umiċeviċ, Canhao, Helena, Ikari, Katsunori, Terao, Chikashi, Okada, Yukinori, Wedrén, Sara, Askling, Johan, Yamanaka, Hisashi, Momohara, Shigeki, Taniguchi, Atsuo, Ohmura, Koichiro, Matsuda, Fumihiko, Mimori, Tsuneyo, Gupta, Namrata, Kuchroo, Manik, Morgan, Ann W., Isaacs, John D., Wilson, Anthony G., Hyrich, Kimme L., Herenius, Marieke, Doorenspleet, Marieke E., Tak, Paul-Peter, Crusius, J. Bart A., van der Horst-Bruinsma, Irene E., Wolbink, Gert Jan, van Riel, Piet L. C. M., van de Laar, Mart, Guchelaar, Henk-Jan, Shadick, Nancy A., Allaart, Cornelia F., Huizinga, Tom W. J., Toes, Rene E. M., Kimberly, Robert P., Bridges, S. Louis, Criswell, Lindsey A., Moreland, Larry W., Fonseca, João Eurico, de Vries, Niek, Stranger, Barbara E., De Jager, Philip L., Raychaudhuri, Soumya, Weinblatt, Michael E., Gregersen, Peter K., Mariette, Xavier, Barton, Anne, Padyukov, Leonid, Coenen, Marieke J. H., Karlson, Elizabeth W., Plenge, Robert M.
Published 2013

Integration of Sequence Data from a Consanguineous Family with Genetic Data from an Outbred Population Identifies PLB1 as a Candidate Rheumatoid Arthritis Risk Gene

by Okada, Yukinori, Diogo, Dorothee, Greenberg, Jeffrey D., Mouassess, Faten, Achkar, Walid A. L., Fulton, Robert S., Denny, Joshua C., Gupta, Namrata, Mirel, Daniel, Gabriel, Stacy, Li, Gang, Kremer, Joel M., Pappas, Dimitrios A., Carroll, Robert J., Eyler, Anne E., Trynka, Gosia, Stahl, Eli A., Cui, Jing, Saxena, Richa, Coenen, Marieke J. H., Guchelaar, Henk-Jan, Huizinga, Tom W. J., Dieudé, Philippe, Mariette, Xavier, Barton, Anne, Canhão, Helena, Fonseca, João E., de Vries, Niek, Tak, Paul P., Moreland, Larry W., Bridges, S. Louis, Miceli-Richard, Corinne, Choi, Hyon K., Kamatani, Yoichiro, Galan, Pilar, Lathrop, Mark, Raj, Towfique, De Jager, Philip L., Raychaudhuri, Soumya, Worthington, Jane, Padyukov, Leonid, Klareskog, Lars, Siminovitch, Katherine A., Gregersen, Peter K., Mardis, Elaine R., Arayssi, Thurayya, Kazkaz, Layla A., Plenge, Robert M.
Published 2014

TYK2 Protein-Coding Variants Protect against Rheumatoid Arthritis and Autoimmunity, with No Evidence of Major Pleiotropic Effects on Non-Autoimmune Complex Traits

by Diogo, Dorothée, Bastarache, Lisa, Liao, Katherine P., Graham, Robert R., Fulton, Robert S., Greenberg, Jeffrey D., Eyre, Steve, Bowes, John, Cui, Jing, Lee, Annette, Pappas, Dimitrios A., Kremer, Joel M., Barton, Anne, Coenen, Marieke J. H., Franke, Barbara, Kiemeney, Lambertus A., Mariette, Xavier, Richard-Miceli, Corrine, Canhão, Helena, Fonseca, João E., de Vries, Niek, Tak, Paul P., Crusius, J. Bart A., Nurmohamed, Michael T., Kurreeman, Fina, Mikuls, Ted R., Okada, Yukinori, Stahl, Eli A., Larson, David E., Deluca, Tracie L., O'Laughlin, Michelle, Fronick, Catrina C., Fulton, Lucinda L., Kosoy, Roman, Ransom, Michael, Bhangale, Tushar R., Ortmann, Ward, Cagan, Andrew, Gainer, Vivian, Karlson, Elizabeth W., Kohane, Isaac, Murphy, Shawn N., Martin, Javier, Zhernakova, Alexandra, Klareskog, Lars, Padyukov, Leonid, Worthington, Jane, Mardis, Elaine R., Seldin, Michael F., Gregersen, Peter K., Behrens, Timothy, Raychaudhuri, Soumya, Denny, Joshua C., Plenge, Robert M.
Published 2015