Clinical development of gene- and cell-based therapies: overview of the European landscape

by de Wilde, Sofieke, Guchelaar, Henk-Jan, Zandvliet, Maarten Laurens, Meij, Pauline
Published 2016

Pharmacokinetics of orally administered uracil in healthy volunteers and in DPD-deficient patients, a possible tool for screening of DPD deficiency

by van Staveren, Maurice C., Theeuwes-Oonk, Barbara, Guchelaar, Henk Jan, van Kuilenburg, André B. P., Maring, Jan Gerard
Published 2011

Dopamine agonists and ischemic complications in Parkinson’s disease: a nested case–control study

by Arbouw, Maurits E. L., Movig, Kris L. L., Guchelaar, Henk-Jan, Neef, Cees, Egberts, Toine C. G.
Published 2011

Genome Wide Association Study for Predictors of Progression Free Survival in Patients on Capecitabine, Oxaliplatin, Bevacizumab and Cetuximab in First-Line Therapy of Metastatic Co...

by Pander, Jan, van Huis-Tanja, Lieke, Böhringer, Stefan, van der Straaten, Tahar, Gelderblom, Hans, Punt, Cornelis, Guchelaar, Henk-Jan
Published 2015

Low literacy and written drug information: information-seeking, leaflet evaluation and preferences, and roles for images

by van Beusekom, Mara M., Grootens-Wiegers, Petronella, Bos, Mark J. W., Guchelaar, Henk-Jan, van den Broek, Jos M.
Published 2016

Genotypes of CYP2C8 and FGD4 and their association with peripheral neuropathy or early dose reduction in paclitaxel-treated breast cancer patients

by Lam, Siu W, Frederiks, Charlotte N, van der Straaten, Tahar, Honkoop, Aafke H, Guchelaar, Henk-Jan, Boven, Epie
Published 2016

Translating Pharmacogenomics: Challenges on the Road to the Clinic

by Swen, Jesse J, Huizinga, Tom W, Gelderblom, Hans, de Vries, Elisabeth G. E, Assendelft, Willem J. J, Kirchheiner, Julia, Guchelaar, Henk-Jan
Published 2007

Statin Use Is Not Associated with Improved Progression Free Survival in Cetuximab Treated KRAS Mutant Metastatic Colorectal Cancer Patients: Results from the CAIRO2 Study

by Krens, Lisanne L., Simkens, Lieke H. J., Baas, Jara M., Koomen, Els R., Gelderblom, Hans, Punt, Cornelis J. A., Guchelaar, Henk-Jan
Published 2014

Effect of gastrointestinal resection on sunitinib exposure in patients with GIST

by de Wit, Djoeke, van Erp, Nielka P, Khosravan, Reza, Wiltshire, Robin, Allred, Randy, Demetri, George D, Guchelaar, Henk-Jan, Gelderblom, Hans
Published 2014

Influence of pharmacogenetic variability on the pharmacokinetics and toxicity of the aurora kinase inhibitor danusertib

by Steeghs, Neeltje, Mathijssen, Ron H. J., Wessels, Judith A. M., de Graan, Anne-Joy, van der Straaten, Tahar, Mariani, Mariangela, Laffranchi, Bernard, Comis, Silvia, de Jonge, Maja J. A., Gelderblom, Hans, Guchelaar, Henk-Jan
Published 2010

Non-Homologous End-Joining Pathway Associated with Occurrence of Myocardial Infarction: Gene Set Analysis of Genome-Wide Association Study Data

by Verschuren, Jeffrey J. W., Trompet, Stella, Deelen, Joris, Stott, David J., Sattar, Naveed, Buckley, Brendan M., Ford, Ian, Heijmans, Bastiaan T., Guchelaar, Henk-Jan, Houwing-Duistermaat, Jeanine J., Slagboom, P. Eline, Jukema, J. Wouter
Published 2013

Association of single nucleotide polymorphisms in IL8 and IL13 with sunitinib-induced toxicity in patients with metastatic renal cell carcinoma

by Diekstra, Meta H. M., Liu, Xiaoyan, Swen, Jesse J., Boven, Epie, Castellano, Daniel, Gelderblom, Hans, Mathijssen, Ron H. J., Rodríguez-Antona, Cristina, García-Donas, Jesus, Rini, Brian I., Guchelaar, Henk-Jan
Published 2015

Influence of Genetic Variants in TPMT and COMT Associated with Cisplatin Induced Hearing Loss in Patients with Cancer: Two New Cohorts and a Meta-Analysis Reveal Significant Hetero...

by Hagleitner, Melanie M., Coenen, Marieke J. H., Patino-Garcia, Ana, de Bont, Eveline S. J. M., Gonzalez-Neira, Anna, Vos, Hanneke I., van Leeuwen, Frank N., Gelderblom, Hans, Hoogerbrugge, Peter M., Guchelaar, Henk-Jan, te Loo, Maroeska W. M.
Published 2014

Insulin-like growth factor 1 receptor expression and IGF1R 3129G > T polymorphism are associated with response to neoadjuvant chemotherapy in breast cancer patients: results from t...

by de Groot, Stefanie, Charehbili, Ayoub, van Laarhoven, Hanneke W. M., Mooyaart, Antien L., Dekker-Ensink, N. Geeske, van de Ven, Saskia, Janssen, Laura G. M., Swen, Jesse J., Smit, Vincent T. H. B. M., Heijns, Joan B., Kessels, Lonneke W., van der Straaten, Tahar, Böhringer, Stefan, Gelderblom, Hans, van der Hoeven, Jacobus J. M., Guchelaar, Henk-Jan, Pijl, Hanno, Kroep, Judith R.
Published 2016

Crowdsourcing genetic prediction of clinical utility in the Rheumatoid Arthritis Responder Challenge

by Plenge, Robert M., Greenberg, Jeffrey D., Mangravite, Lara M., Derry, Jonathan M. J., Stahl, Eli A., Coenen, Marieke J. H., Barton, Anne, Padyukov, Leonid, Klareskog, Lars, Gregersen, Peter K., Mariette, Xavier, Moreland, Larry W., Bridges, S Louis, de Vries, Niek, Huizinga, Tom W. J., Guchelaar, Henk-Jan, Friend, Stephen H., Stolovitzky, Gustavo
Published 2013

Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis

by Cui, Jing, Stahl, Eli A., Saevarsdottir, Saedis, Miceli, Corinne, Diogo, Dorothee, Trynka, Gosia, Raj, Towfique, Mirkov, Maša Umiċeviċ, Canhao, Helena, Ikari, Katsunori, Terao, Chikashi, Okada, Yukinori, Wedrén, Sara, Askling, Johan, Yamanaka, Hisashi, Momohara, Shigeki, Taniguchi, Atsuo, Ohmura, Koichiro, Matsuda, Fumihiko, Mimori, Tsuneyo, Gupta, Namrata, Kuchroo, Manik, Morgan, Ann W., Isaacs, John D., Wilson, Anthony G., Hyrich, Kimme L., Herenius, Marieke, Doorenspleet, Marieke E., Tak, Paul-Peter, Crusius, J. Bart A., van der Horst-Bruinsma, Irene E., Wolbink, Gert Jan, van Riel, Piet L. C. M., van de Laar, Mart, Guchelaar, Henk-Jan, Shadick, Nancy A., Allaart, Cornelia F., Huizinga, Tom W. J., Toes, Rene E. M., Kimberly, Robert P., Bridges, S. Louis, Criswell, Lindsey A., Moreland, Larry W., Fonseca, João Eurico, de Vries, Niek, Stranger, Barbara E., De Jager, Philip L., Raychaudhuri, Soumya, Weinblatt, Michael E., Gregersen, Peter K., Mariette, Xavier, Barton, Anne, Padyukov, Leonid, Coenen, Marieke J. H., Karlson, Elizabeth W., Plenge, Robert M.
Published 2013

Integration of Sequence Data from a Consanguineous Family with Genetic Data from an Outbred Population Identifies PLB1 as a Candidate Rheumatoid Arthritis Risk Gene

by Okada, Yukinori, Diogo, Dorothee, Greenberg, Jeffrey D., Mouassess, Faten, Achkar, Walid A. L., Fulton, Robert S., Denny, Joshua C., Gupta, Namrata, Mirel, Daniel, Gabriel, Stacy, Li, Gang, Kremer, Joel M., Pappas, Dimitrios A., Carroll, Robert J., Eyler, Anne E., Trynka, Gosia, Stahl, Eli A., Cui, Jing, Saxena, Richa, Coenen, Marieke J. H., Guchelaar, Henk-Jan, Huizinga, Tom W. J., Dieudé, Philippe, Mariette, Xavier, Barton, Anne, Canhão, Helena, Fonseca, João E., de Vries, Niek, Tak, Paul P., Moreland, Larry W., Bridges, S. Louis, Miceli-Richard, Corinne, Choi, Hyon K., Kamatani, Yoichiro, Galan, Pilar, Lathrop, Mark, Raj, Towfique, De Jager, Philip L., Raychaudhuri, Soumya, Worthington, Jane, Padyukov, Leonid, Klareskog, Lars, Siminovitch, Katherine A., Gregersen, Peter K., Mardis, Elaine R., Arayssi, Thurayya, Kazkaz, Layla A., Plenge, Robert M.
Published 2014

Erratum to: Making sense of big data in health research: towards an EU action plan

by Auffray, Charles, Balling, Rudi, Barroso, Inês, Bencze, László, Benson, Mikael, Bergeron, Jay, Bernal-Delgado, Enrique, Blomberg, Niklas, Bock, Christoph, Conesa, Ana, Del Signore, Susanna, Delogne, Christophe, Devilee, Peter, Di Meglio, Alberto, Eijkemans, Marinus, Flicek, Paul, Graf, Norbert, Grimm, Vera, Guchelaar, Henk-Jan, Guo, Yi-Ke, Gut, Ivo Glynne, Hanbury, Allan, Hanif, Shahid, Hilgers, Ralf-Dieter, Honrado, Ángel, Hose, D. Rod, Houwing-Duistermaat, Jeanine, Hubbard, Tim, Janacek, Sophie Helen, Karanikas, Haralampos, Kievits, Tim, Kohler, Manfred, Kremer, Andreas, Lanfear, Jerry, Lengauer, Thomas, Maes, Edith, Meert, Theo, Müller, Werner, Nickel, Dörthe, Oledzki, Peter, Pedersen, Bertrand, Petkovic, Milan, Pliakos, Konstantinos, Rattray, Magnus, i Màs, Josep Redón, Schneider, Reinhard, Sengstag, Thierry, Serra-Picamal, Xavier, Spek, Wouter, Vaas, Lea A. I., van Batenburg, Okker, Vandelaer, Marc, Varnai, Peter, Villoslada, Pablo, Vizcaíno, Juan Antonio, Wubbe, John Peter Mary, Zanetti, Gianluigi
Published 2016

Making sense of big data in health research: Towards an EU action plan

by Auffray, Charles, Balling, Rudi, Barroso, Inês, Bencze, László, Benson, Mikael, Bergeron, Jay, Bernal-Delgado, Enrique, Blomberg, Niklas, Bock, Christoph, Conesa, Ana, Del Signore, Susanna, Delogne, Christophe, Devilee, Peter, Di Meglio, Alberto, Eijkemans, Marinus, Flicek, Paul, Graf, Norbert, Grimm, Vera, Guchelaar, Henk-Jan, Guo, Yi-Ke, Gut, Ivo Glynne, Hanbury, Allan, Hanif, Shahid, Hilgers, Ralf-Dieter, Honrado, Ángel, Hose, D. Rod, Houwing-Duistermaat, Jeanine, Hubbard, Tim, Janacek, Sophie Helen, Karanikas, Haralampos, Kievits, Tim, Kohler, Manfred, Kremer, Andreas, Lanfear, Jerry, Lengauer, Thomas, Maes, Edith, Meert, Theo, Müller, Werner, Nickel, Dörthe, Oledzki, Peter, Pedersen, Bertrand, Petkovic, Milan, Pliakos, Konstantinos, Rattray, Magnus, i Màs, Josep Redón, Schneider, Reinhard, Sengstag, Thierry, Serra-Picamal, Xavier, Spek, Wouter, Vaas, Lea A. I., van Batenburg, Okker, Vandelaer, Marc, Varnai, Peter, Villoslada, Pablo, Vizcaíno, Juan Antonio, Wubbe, John Peter Mary, Zanetti, Gianluigi
Published 2016

Genetics of rheumatoid arthritis contributes to biology and drug discovery

by Okada, Yukinori, Wu, Di, Trynka, Gosia, Raj, Towfique, Terao, Chikashi, Ikari, Katsunori, Kochi, Yuta, Ohmura, Koichiro, Suzuki, Akari, Yoshida, Shinji, Graham, Robert R., Manoharan, Arun, Ortmann, Ward, Bhangale, Tushar, Denny, Joshua C., Carroll, Robert J., Eyler, Anne E., Greenberg, Jeffrey D., Kremer, Joel M., Pappas, Dimitrios A., Jiang, Lei, Yin, Jian, Ye, Lingying, Su, Ding-Feng, Yang, Jian, Xie, Gang, Keystone, Ed, Westra, Harm-Jan, Esko, Tõnu, Metspalu, Andres, Zhou, Xuezhong, Gupta, Namrata, Mirel, Daniel, Stahl, Eli A., Diogo, Dorothée, Cui, Jing, Liao, Katherine, Guo, Michael H., Myouzen, Keiko, Kawaguchi, Takahisa, Coenen, Marieke J.H., van Riel, Piet L.C.M., van de Laar, Mart A.F.J., Guchelaar, Henk-Jan, Huizinga, Tom W.J., Dieudé, Philippe, Mariette, Xavier, Bridges, S. Louis, Zhernakova, Alexandra, Toes, Rene E.M., Tak, Paul P., Miceli-Richard, Corinne, Bang, So-Young, Lee, Hye-Soon, Martin, Javier, Gonzalez-Gay, Miguel A., Rodriguez-Rodriguez, Luis, Rantapää-Dahlqvist, Solbritt, Ärlestig, Lisbeth, Choi, Hyon K., Kamatani, Yoichiro, Galan, Pilar, Lathrop, Mark, Eyre, Steve, Bowes, John, Barton, Anne, de Vries, Niek, Moreland, Larry W., Criswell, Lindsey A., Karlson, Elizabeth W., Taniguchi, Atsuo, Yamada, Ryo, Kubo, Michiaki, Liu, Jun S., Bae, Sang-Cheol, Worthington, Jane, Padyukov, Leonid, Klareskog, Lars, Gregersen, Peter K., Raychaudhuri, Soumya, Stranger, Barbara E., De Jager, Philip L., Franke, Lude, Visscher, Peter M., Brown, Matthew A., Yamanaka, Hisashi, Mimori, Tsuneyo, Takahashi, Atsushi, Xu, Huji, Behrens, Timothy W., Siminovitch, Katherine A., Momohara, Shigeki, Matsuda, Fumihiko, Yamamoto, Kazuhiko, Plenge, Robert M.
Published 2013