High-Throughput Screen in Cryptococcus neoformans Identifies a Novel Molecular Scaffold That Inhibits Cell Wall Integrity Pathway Signaling

by Hartland, Kate, Pu, Jun, Palmer, Michelle, Dandapani, Sivaraman, Moquist, Philip N., Munoz, Benito, DiDone, Louis, Schreiber, Stuart L., Krysan, Damian J.
Published 2015

Discovery of 1,3-Diaminobenzenes as Selective Inhibitors of Platelet Activation at the PAR1 Receptor

by Dockendorff, Chris, Aisiku, Omozuanvbo, VerPlank, Lynn, Dilks, James R., Smith, Daniel A., Gunnink, Susanna F., Dowal, Louisa, Negri, Joseph, Palmer, Michelle, MacPherson, Lawrence, Schreiber, Stuart L., Flaumenhaft, Robert
Published 2012

ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans

by Youngsaye, Willmen, Hartland, Cathy L, Morgan, Barbara J, Ting, Amal, Nag, Partha P, Vincent, Benjamin, Mosher, Carrie A, Bittker, Joshua A, Dandapani, Sivaraman, Palmer, Michelle, Whitesell, Luke, Lindquist, Susan, Schreiber, Stuart L, Munoz, Benito
Published 2013

A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells

by Weïwer, Michel, Spoonamore, James, Wei, Jingqiang, Guichard, Boris, Ross, Nathan T., Masson, Kristina, Silkworth, Whitney, Dandapani, Sivaraman, Palmer, Michelle, Scherer, Christina A., Stern, Andrew M., Schreiber, Stuart L., Munoz, Benito
Published 2012

Modulators of Hepatic Lipoprotein Metabolism Identified in a Search for Small-Molecule Inducers of Tribbles Pseudokinase 1 Expression

by Nagiec, Marek M., Skepner, Adam P., Negri, Joseph, Eichhorn, Michelle, Kuperwasser, Nicolas, Comer, Eamon, Muncipinto, Giovanni, Subramanian, Aravind, Clish, Clary, Musunuru, Kiran, Duvall, Jeremy R., Foley, Michael, Perez, Jose R., Palmer, Michelle A. J.
Published 2015

Identification of a Small Molecule that Increases Hemoglobin Oxygen Affinity and Reduces SS Erythrocyte Sickling

by Nakagawa, Akito, Lui, Francine E., Wassaf, Dina, Yefidoff-Freedman, Revital, Casalena, Dominick, Palmer, Michelle A., Meadows, Jacqueline, Mozzarelli, Andrea, Ronda, Luca, Abdulmalik, Osheiza, Bloch, Kenneth D., Safo, Martin K., Zapol, Warren M.
Published 2014

Identification of Inhibitors of PvdQ, an Enzyme Involved in the Synthesis of the Siderophore Pyoverdine

by Wurst, Jacqueline M., Drake, Eric J., Theriault, Jimmy R., Jewett, Ivan T., VerPlank, Lynn, Perez, Jose R., Dandapani, Sivaraman, Palmer, Michelle, Moskowitz, Samuel M., Schreiber, Stuart L., Munoz, Benito, Gulick, Andrew M.
Published 2014

Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies

by Dockendorff, Chris, Nagiec, Marek M., Weïwer, Michel, Buhrlage, Sara, Ting, Amal, Nag, Partha P., Germain, Andrew, Kim, Han-Je, Youngsaye, Willmen, Scherer, Christina, Bennion, Melissa, Xue, Linlong, Stanton, Benjamin Z., Lewis, Timothy A., MacPherson, Lawrence, Palmer, Michelle, Foley, Michael A., Perez, José R., Schreiber, Stuart L.
Published 2012

Indolinyl-Thiazole Based Inhibitors of Scavenger Receptor-BI (SR-BI)-Mediated Lipid Transport

by Dockendorff, Chris, Faloon, Patrick W., Yu, Miao, Youngsaye, Willmen, Penman, Marsha, Nieland, Thomas J. F., Nag, Partha P., Lewis, Timothy A., Pu, Jun, Bennion, Melissa, Negri, Joseph, Paterson, Conor, Lam, Garrett, Dandapani, Sivaraman, Perez, José R., Munoz, Benito, Palmer, Michelle A., Schreiber, Stuart L., Krieger, Monty
Published 2015

Diversity-Oriented Synthesis-Facilitated Medicinal Chemistry: Toward the Development of Novel Antimalarial Agents

by Comer, Eamon, Beaudoin, Jennifer A., Kato, Nobutaka, Fitzgerald, Mark E., Heidebrecht, Richard W., Lee, Maurice duPont, Masi, Daniela, Mercier, Marion, Mulrooney, Carol, Muncipinto, Giovanni, Rowley, Ann, Crespo-Llado, Keila, Serrano, Adelfa E., Lukens, Amanda K., Wiegand, Roger C., Wirth, Dyann F., Palmer, Michelle A., Foley, Michael A., Munoz, Benito, Scherer, Christina A., Duvall, Jeremy R., Schreiber, Stuart L.
Published 2014

Diversity-Oriented Synthesis Probe Targets Plasmodium falciparum Cytochrome b Ubiquinone Reduction Site and Synergizes With Oxidation Site Inhibitors

by Lukens, Amanda K., Heidebrecht, Richard W., Mulrooney, Carol, Beaudoin, Jennifer A., Comer, Eamon, Duvall, Jeremy R., Fitzgerald, Mark E., Masi, Daniela, Galinsky, Kevin, Scherer, Christina A., Palmer, Michelle, Munoz, Benito, Foley, Michael, Schreiber, Stuart L., Wiegand, Roger C., Wirth, Dyann F.
Published 2015

Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria

by Heidebrecht, Richard W., Mulrooney, Carol, Austin, Christopher P., Barker, Robert H., Beaudoin, Jennifer A., Cheng, Ken Chih-Chien, Comer, Eamon, Dandapani, Sivaraman, Dick, Justin, Duvall, Jeremy R., Ekland, Eric H., Fidock, David A., Fitzgerald, Mark E., Foley, Michael, Guha, Rajarshi, Hinkson, Paul, Kramer, Martin, Lukens, Amanda K., Masi, Daniela, Marcaurelle, Lisa A., Su, Xin-Zhuan, Thomas, Craig J., Weïwer, Michel, Wiegand, Roger C., Wirth, Dyann, Xia, Menghang, Yuan, Jing, Zhao, Jinghua, Palmer, Michelle, Munoz, Benito, Schreiber, Stuart
Published 2011

Correlating chemical sensitivity and basal gene expression reveals mechanism of action

by Rees, Matthew G., Seashore-Ludlow, Brinton, Cheah, Jaime H., Adams, Drew J., Price, Edmund V., Gill, Shubhroz, Javaid, Sarah, Coletti, Matthew E., Jones, Victor L., Bodycombe, Nicole E., Soule, Christian K., Alexander, Benjamin, Li, Ava, Montgomery, Philip, Kotz, Joanne D., Hon, C. Suk-Yee, Munoz, Benito, Liefeld, Ted, Dančík, Vlado, Haber, Daniel A., Clish, Clary B., Bittker, Joshua A., Palmer, Michelle, Wagner, Bridget K., Clemons, Paul A., Shamji, Alykhan F., Schreiber, Stuart L.
Published 2015