One remarkable molecule: Filaggrin

by Brown, Sara J., McLean, W. H. Irwin
Published 2011

Obtaining DNA in the mail from a national sample of children with a chronic non-fatal illness

by Margolis, David J., Papadopoulos, Maryte, Apter, Andrea, McLean, W. H. Irwin, Mitra, Nandita, Rebbeck, Tim
Published 2011

A Lack of Premature Termination Codon Read-Through Efficacy of PTC124 (Ataluren) in a Diverse Array of Reporter Assays

by McElroy, Stuart P., Nomura, Toshifumi, Torrie, Leah S., Warbrick, Emma, Gartner, Ulrike, Wood, Gavin, McLean, W. H. Irwin
Published 2013

Intragenic Copy Number Variation within Filaggrin Contributes to the Risk of Atopic Dermatitis with a Dose-Dependent Effect

by Brown, Sara J, Kroboth, Karin, Sandilands, Aileen, Campbell, Linda E, Pohler, Elizabeth, Kezic, Sanja, Cordell, Heather J, McLean, W H Irwin, Irvine, Alan D
Published 2012

Improved Annotation of 3′ Untranslated Regions and Complex Loci by Combination of Strand-Specific Direct RNA Sequencing, RNA-Seq and ESTs

by Schurch, Nicholas J., Cole, Christian, Sherstnev, Alexander, Song, Junfang, Duc, Céline, Storey, Kate G., McLean, W. H. Irwin, Brown, Sara J., Simpson, Gordon G., Barton, Geoffrey J.
Published 2014

In vivo gene silencing following non-invasive siRNA delivery into the skin using a novel topical formulation

by Hegde, Vikas, Hickerson, Robyn P., Nainamalai, Sitheswaran, Campbell, Paul A., Smith, Frances J.D., McLean, W.H. Irwin, Leslie Pedrioli, Deena M.
Published 2014

Skin barrier dysfunction measured by transepidermal water loss at 2 days and 2 months predates and predicts atopic dermatitis at 1 year

by Kelleher, Maeve, Dunn-Galvin, Audrey, Hourihane, Jonathan O'B., Murray, Deirdre, Campbell, Linda E., McLean, W.H. Irwin, Irvine, Alan D.
Published 2015

Development of Allele-Specific Therapeutic siRNA in Meesmann Epithelial Corneal Dystrophy

by Liao, Haihui, Irvine, Alan D., MacEwen, Caroline J., Weed, Kathryn H., Porter, Louise, Corden, Laura D., Gibson, A. Bethany, Moore, Jonathan E., Smith, Frances J. D., McLean, W. H. Irwin, Moore, C. B. Tara
Published 2011

Mutations in the SASPase gene (ASPRV1) are not associated with atopic eczema or clinically dry skin

by Sandilands, Aileen, Brown, Sara J., Goh, Christabelle S., Pohler, Elizabeth, Wilson, Neil J., Campbell, Linda E., Miyamoto, Kenichi, Kubo, Akiharu, Irvine, Alan D., Thawer-Esmail, Fatema, Munro, Colin S., McLean, W.H. Irwin, Kudoh, Jun, Amagai, Masayuki, Matsui, Takeshi
Published 2012

Raman profiles of the stratum corneum define 3 filaggrin genotype–determined atopic dermatitis endophenotypes

by O'Regan, Gráinne M., Kemperman, Patrick M.J.H., Sandilands, Aileen, Chen, Huijia, Campbell, Linda E., Kroboth, Karin, Watson, Rosemarie, Rowland, Marion, Puppels, Gerwin J., McLean, W.H. Irwin, Caspers, Peter J., Irvine, Alan D.
Published 2010

Generation and Characterisation of Keratin 7 (K7) Knockout Mice

by Sandilands, Aileen, Smith, Frances J. D., Lunny, Declan P., Campbell, Linda E., Davidson, Kirsty M., MacCallum, Stephanie F., Corden, Laura D., Christie, Lesley, Fleming, Stewart, Lane, E. Birgitte, McLean, W. H. Irwin
Published 2013

Filaggrin gene mutation associations with peanut allergy persist despite variations in peanut allergy diagnostic criteria or asthma status

by Asai, Yuka, Greenwood, Celia, Hull, Peter R., Alizadehfar, Reza, Ben-Shoshan, Moshe, Brown, Sara J., Campbell, Linda, Michel, Deborah L., Bussières, Johanne, Rousseau, François, Fujiwara, T. Mary, Morgan, Kenneth, Irvine, Alan D., McLean, W.H. Irwin, Clarke, Ann
Published 2013

Report of the tenth annual International Pachyonychia Congenita Consortium meeting

by van Steensel, Maurice A.M., Coulombe, Pierre A., Kaspar, Roger L., Milstone, Leonard M., McLean, W.H. Irwin, Roop, Dennis R., Smith, Frances J.D., Sprecher, Eli, Schwartz, Mary E.
Published 2014

South African amaXhosa patients with atopic dermatitis have decreased levels of filaggrin breakdown products but no loss-of-function mutations in filaggrin☆

by Thawer-Esmail, Fatemah, Jakasa, Ivone, Todd, Gail, Wen, Yaran, Brown, Sara J., Kroboth, Karin, Campbell, Linda E., O'Regan, Grainne M., McLean, W.H. Irwin, Irvine, Alan D., Kezic, Sanja, Sandilands, Aileen
Published 2014

Filaggrin genotype does not determine the skin's threshold to UV-induced erythema

by Forbes, Deborah, Johnston, Leona, Gardner, June, MacCallum, Stephanie F., Campbell, Linda E., Dinkova-Kostova, Albena T., McLean, W.H. Irwin, Ibbotson, Sally H., Dawe, Robert S., Brown, Sara J.
Published 2016

Filaggrin breakdown products determine corneocyte conformation in patients with atopic dermatitis

by Riethmuller, Christoph, McAleer, Maeve A., Koppes, Sjors A., Abdayem, Rawad, Franz, Jonas, Haftek, Marek, Campbell, Linda E., MacCallum, Stephanie F., McLean, W.H. Irwin, Irvine, Alan D., Kezic, Sanja
Published 2015

Expanding the Phenotypic Spectrum of Olmsted Syndrome

by Wilson, Neil J, Cole, Christian, Milstone, Leonard M, Kiszewski, Ana E, Hansen, C David, O'Toole, Edel A, Schwartz, Mary E, McLean, W H Irwin, Smith, Frances J D
Published 2015

Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention

by Simpson, Eric L., Chalmers, Joanne R., Hanifin, Jon M., Thomas, Kim S., Cork, Michael J., McLean, W.H. Irwin, Brown, Sara J., Chen, Zunqiu, Chen, Yiyi, Williams, Hywel C.
Published 2014

Peanut allergy: Effect of environmental peanut exposure in children with filaggrin loss-of-function mutations

by Brough, Helen A., Simpson, Angela, Makinson, Kerry, Hankinson, Jenny, Brown, Sara, Douiri, Abdel, Belgrave, Danielle C.M., Penagos, Martin, Stephens, Alick C., McLean, W.H. Irwin, Turcanu, Victor, Nicolaou, Nicolaos, Custovic, Adnan, Lack, Gideon
Published 2014

Filaggrin loss-of-function mutations and atopic dermatitis as risk factors for hand eczema in apprentice nurses: part II of a prospective cohort study

by Visser, Maaike J, Verberk, Maarten M, Campbell, Linda E, McLean, W H Irwin, Calkoen, Florentine, Bakker, Jan G, van Dijk, Frank J H, Bos, Jan D, Kezic, Sanja
Published 2014