In vivo gene silencing following non-invasive siRNA delivery into the skin using a novel topical formulation

In vivo gene silencing following non-invasive siRNA delivery into the skin using a novel topical formulation

Therapeutics based on short interfering RNAs (siRNAs), which act by inhibiting the expression of target transcripts, represent a novel class of potent and highly specific next-generation treatments for human skin diseases. Unfortunately, the intrinsic barrier properties of the skin combined with the...

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Bibliographic Details
Main Authors: Hegde, Vikas, Hickerson, Robyn P., Nainamalai, Sitheswaran, Campbell, Paul A., Smith, Frances J.D., McLean, W.H. Irwin, Leslie Pedrioli, Deena M.
Format: Online
Language:English
Published: Elsevier Science Publishers 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275573/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275573/

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