The D-type prostanoid (DP) receptor enhances the signaling of chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)

by Sedej, Miriam, Schröder, Ralf, Bell, Kathrin, Platzer, Wolfgang, Kostenis, Evi, Heinemann, Ákos, Waldhoer, Maria
Published 2011

Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation

by Uller, Lena, Mathiesen, Jesper Mosolff, Alenmyr, Lisa, Korsgren, Magnus, Ulven, Trond, Högberg, Thomas, Andersson, Gunnar, Persson, Carl GA, Kostenis, Evi
Published 2007

Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs

by Hudson, Brian D., Christiansen, Elisabeth, Tikhonova, Irina G., Grundmann, Manuel, Kostenis, Evi, Adams, David R., Ulven, Trond, Milligan, Graeme
Published 2012

Targeted inhibition of Gq signaling induces airway relaxation in mouse models of asthma

by Matthey, Michaela, Roberts, Richard, Seidinger, Alexander, Simon, Annika, Schröder, Ralf, Kuschak, Markus, Annala, Suvi, König, Gabriele M., Müller, Christa E., Hall, Ian P., Kostenis, Evi, Wenzel, Daniela
Published 2017

PGH1, the Precursor for the Anti-Inflammatory Prostaglandins of the 1-series, Is a Potent Activator of the Pro-Inflammatory Receptor CRTH2/DP2

by Schröder, Ralf, Xue, Luzheng, Konya, Viktoria, Martini, Lene, Kampitsch, Nora, Whistler, Jennifer L., Ulven, Trond, Heinemann, Akos, Pettipher, Roy, Kostenis, Evi
Published 2012

Selective Orthosteric Free Fatty Acid Receptor 2 (FFA2) Agonists: IDENTIFICATION OF THE STRUCTURAL AND CHEMICAL REQUIREMENTS FOR SELECTIVE ACTIVATION OF FFA2 VERSUS FFA3*

by Schmidt, Johannes, Smith, Nicola J., Christiansen, Elisabeth, Tikhonova, Irina G., Grundmann, Manuel, Hudson, Brian D., Ward, Richard J., Drewke, Christel, Milligan, Graeme, Kostenis, Evi, Ulven, Trond
Published 2011

Pseudomonas aeruginosa ExoY, a cyclic GMP- and cyclic UMP-generating nucleotidyl cyclase

by Seifert, Roland, Hartwig, Christina, Wolter, Sabine, Reinecke, Daniel, Burhenne, Heike, Kaever, Volkhard, Munder, Antje, Tümmler, Burkhard, Schwede, Frank, Grundmann, Manuel, Kostenis, Evi, Frank, Dara W, Beckert, Ulrike
Published 2013

Reevaluation of Fatty Acid Receptor 1 as a Drug Target for the Stimulation of Insulin Secretion in Humans

by Wagner, Robert, Kaiser, Gabriele, Gerst, Felicia, Christiansen, Elisabeth, Due-Hansen, Maria E., Grundmann, Manuel, Machicao, Fausto, Peter, Andreas, Kostenis, Evi, Ulven, Trond, Fritsche, Andreas, Häring, Hans-Ulrich, Ullrich, Susanne
Published 2013

The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling

by Bock, Andreas, Merten, Nicole, Schrage, Ramona, Dallanoce, Clelia, Bätz, Julia, Klöckner, Jessica, Schmitz, Jens, Matera, Carlo, Simon, Katharina, Kebig, Anna, Peters, Lucas, Müller, Anke, Schrobang-Ley, Jasmin, Tränkle, Christian, Hoffmann, Carsten, De Amici, Marco, Holzgrabe, Ulrike, Kostenis, Evi, Mohr, Klaus
Published 2012

Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes

by Christiansen, Elisabeth, Hansen, Steffen V. F., Urban, Christian, Hudson, Brian D., Wargent, Edward T., Grundmann, Manuel, Jenkins, Laura, Zaibi, Mohamed, Stocker, Claire J., Ullrich, Susanne, Kostenis, Evi, Kassack, Matthias U., Milligan, Graeme, Cawthorne, Michael A., Ulven, Trond
Published 2013

A Novel Allosteric Activator of Free Fatty Acid 2 Receptor Displays Unique Gi-functional Bias*

by Bolognini, Daniele, Moss, Catherine E., Nilsson, Karolina, Petersson, Annika U., Donnelly, Iona, Sergeev, Eugenia, König, Gabriele M., Kostenis, Evi, Kurowska-Stolarska, Mariola, Miller, Ashley, Dekker, Niek, Tobin, Andrew B., Milligan, Graeme
Published 2016

The Gq signalling pathway inhibits brown and beige adipose tissue

by Klepac, Katarina, Kilić, Ana, Gnad, Thorsten, Brown, Loren M., Herrmann, Beate, Wilderman, Andrea, Balkow, Aileen, Glöde, Anja, Simon, Katharina, Lidell, Martin E., Betz, Matthias J., Enerbäck, Sven, Wess, Jürgen, Freichel, Marc, Blüher, Matthias, König, Gabi, Kostenis, Evi, Insel, Paul A., Pfeifer, Alexander
Published 2016

The experimental power of FR900359 to study Gq-regulated biological processes

by Schrage, Ramona, Schmitz, Anna-Lena, Gaffal, Evelyn, Annala, Suvi, Kehraus, Stefan, Wenzel, Daniela, Büllesbach, Katrin M., Bald, Tobias, Inoue, Asuka, Shinjo, Yuji, Galandrin, Ségolène, Shridhar, Naveen, Hesse, Michael, Grundmann, Manuel, Merten, Nicole, Charpentier, Thomas H., Martz, Matthew, Butcher, Adrian J., Slodczyk, Tanja, Armando, Sylvain, Effern, Maike, Namkung, Yoon, Jenkins, Laura, Horn, Velten, Stößel, Anne, Dargatz, Harald, Tietze, Daniel, Imhof, Diana, Galés, Céline, Drewke, Christel, Müller, Christa E., Hölzel, Michael, Milligan, Graeme, Tobin, Andrew B., Gomeza, Jesús, Dohlman, Henrik G., Sondek, John, Harden, T. Kendall, Bouvier, Michel, Laporte, Stéphane A., Aoki, Junken, Fleischmann, Bernd K., Mohr, Klaus, König, Gabriele M., Tüting, Thomas, Kostenis, Evi
Published 2015