Short-term information processing, long-term responses: Insights by mathematical modeling of signal transduction: Early activation dynamics of key signaling mediators can be predic...

by Schneider, Annette, Klingmüller, Ursula, Schilling, Marcel
Published 2012

Hepatocellular carcinoma: a systems biology perspective

by D'Alessandro, Lorenza A., Meyer, René, Klingmüller, Ursula
Published 2013

An integrative model links multiple inputs and signaling pathways to the onset of DNA synthesis in hepatocytes

by Huard, Jérémy, Mueller, Stephanie, Gilles, Ernst D, Klingmüller, Ursula, Klamt, Steffen
Published 2012

High-Content Imaging Platform for Profiling Intracellular Signaling Network Activity in Living Cells

by Kuchenov, Dmitry, Laketa, Vibor, Stein, Frank, Salopiata, Florian, Klingmüller, Ursula, Schultz, Carsten
Published 2016

Leukemogenic Ptpn11 Allele Causes Defective Erythropoiesis in Mice

by Usenko, Tatiana, Chan, Gordon, Torlakovic, Emina, Klingmüller, Ursula, Neel, Benjamin G.
Published 2014

In silico labeling reveals the time-dependent label half-life and transit-time in dynamical systems

by Maiwald, Thomas, Blumberg, Julie, Raue, Andreas, Hengl, Stefan, Schilling, Marcel, Sy, Sherwin KB, Becker, Verena, Klingmüller, Ursula, Timmer, Jens
Published 2012

Prognostic Significance of Erythropoietin in Pancreatic Adenocarcinoma

by Welsch, Thilo, Zschäbitz, Stefanie, Becker, Verena, Giese, Thomas, Bergmann, Frank, Hinz, Ulf, Keleg, Shereen, Heller, Anette, Sipos, Bence, Klingmüller, Ursula, Büchler, Markus W., Werner, Jens, Giese, Nathalia A.
Published 2011

Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range

by Bachmann, Julie, Raue, Andreas, Schilling, Marcel, Böhm, Martin E, Kreutz, Clemens, Kaschek, Daniel, Busch, Hauke, Gretz, Norbert, Lehmann, Wolf D, Timmer, Jens, Klingmüller, Ursula
Published 2011

Lessons Learned from Quantitative Dynamical Modeling in Systems Biology

by Raue, Andreas, Schilling, Marcel, Bachmann, Julie, Matteson, Andrew, Schelke, Max, Kaschek, Daniel, Hug, Sabine, Kreutz, Clemens, Harms, Brian D., Theis, Fabian J., Klingmüller, Ursula, Timmer, Jens
Published 2013

Correction: Lessons Learned from Quantitative Dynamical Modeling in Systems Biology

by Raue, Andreas, Schilling, Marcel, Bachmann, Julie, Matteson, Andrew, Schelker, Max, Kaschek, Daniel, Hug, Sabine, Kreutz, Clemens, Harms, Brian D., Theis, Fabian J., Klingmüller, Ursula, Timmer, Jens
Published 2013

The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis

by Kuhns, Stefanie, Schmidt, Kerstin N., Reymann, Jürgen, Gilbert, Daniel F., Neuner, Annett, Hub, Birgit, Carvalho, Ricardo, Wiedemann, Philipp, Zentgraf, Hanswalter, Erfle, Holger, Klingmüller, Ursula, Boutros, Michael, Pereira, Gislene
Published 2013

Hepatocyte-specific S100a8 and S100a9 transgene expression in mice causes Cxcl1 induction and systemic neutrophil enrichment

by Wiechert, Lars, Németh, Julia, Pusterla, Tobias, Bauer, Christine, De Ponti, Aurora, Manthey, Sandra, Marhenke, Silke, Vogel, Arndt, Klingmüller, Ursula, Hess, Jochen, Angel, Peter
Published 2012

A Systems Biology Study on NFκB Signaling in Primary Mouse Hepatocytes

by Pinna, Federico, Sahle, Sven, Beuke, Katharina, Bissinger, Michaela, Tuncay, Selcan, D’Alessandro, Lorenza A., Gauges, Ralph, Raue, Andreas, Timmer, Jens, Klingmüller, Ursula, Schirmacher, Peter, Kummer, Ursula, Breuhahn, Kai
Published 2012

A Thymic Epithelial Stem Cell Pool Persists throughout Ontogeny and Is Modulated by TGF-β

by Ucar, Olga, Li, Kaiyong, Dvornikov, Dmytro, Kreutz, Clemens, Timmer, Jens, Matt, Sonja, Brenner, Lukas, Smedley, Catherine, Travis, Mark A., Hofmann, Thomas G., Klingmüller, Ursula, Kyewski, Bruno
Published 2016

Erythropoietin Improves the Accumulation and Therapeutic Effects of Carboplatin by Enhancing Tumor Vascularization and Perfusion

by Doleschel, Dennis, Rix, Anne, Arns, Susanne, Palmowski, Karin, Gremse, Felix, Merkle, Ruth, Salopiata, Florian, Klingmüller, Ursula, Jarsch, Michael, Kiessling, Fabian, Lederle, Wiltrud
Published 2015

T160-phosphorylated CDK2 defines threshold for HGF-dependent proliferation in primary hepatocytes

by Mueller, Stephanie, Huard, Jérémy, Waldow, Katharina, Huang, Xiaoyun, D'Alessandro, Lorenza A, Bohl, Sebastian, Börner, Kathleen, Grimm, Dirk, Klamt, Steffen, Klingmüller, Ursula, Schilling, Marcel
Published 2015

Heterogeneous kinetics of AKT signaling in individual cells are accounted for by variable protein concentration

by Meyer, René, D'Alessandro, Lorenza A., Kar, Sandip, Kramer, Bernhard, She, Bin, Kaschek, Daniel, Hahn, Bettina, Wrangborg, David, Karlsson, Johan, Kvarnström, Mats, Jirstrand, Mats, Lehmann, Wolf-Dieter, Timmer, Jens, Höfer, Thomas, Klingmüller, Ursula
Published 2012

Identification of Cell Type-Specific Differences in Erythropoietin Receptor Signaling in Primary Erythroid and Lung Cancer Cells

by Merkle, Ruth, Steiert, Bernhard, Salopiata, Florian, Depner, Sofia, Raue, Andreas, Iwamoto, Nao, Schelker, Max, Hass, Helge, Wäsch, Marvin, Böhm, Martin E., Mücke, Oliver, Lipka, Daniel B., Plass, Christoph, Lehmann, Wolf D., Kreutz, Clemens, Timmer, Jens, Schilling, Marcel, Klingmüller, Ursula
Published 2016

Disentangling the Complexity of HGF Signaling by Combining Qualitative and Quantitative Modeling

by D’Alessandro, Lorenza A., Samaga, Regina, Maiwald, Tim, Rho, Seong-Hwan, Bonefas, Sandra, Raue, Andreas, Iwamoto, Nao, Kienast, Alexandra, Waldow, Katharina, Meyer, Rene, Schilling, Marcel, Timmer, Jens, Klamt, Steffen, Klingmüller, Ursula
Published 2015