High-Content Imaging Platform for Profiling Intracellular Signaling Network Activity in Living Cells

Essential characteristics of cellular signaling networks include a complex interconnected architecture and temporal dynamics of protein activity. The latter can be monitored by Förster resonance energy transfer (FRET) biosensors at a single-live-cell level with high temporal resolution. However, the...

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Bibliographic Details
Main Authors: Kuchenov, Dmitry, Laketa, Vibor, Stein, Frank, Salopiata, Florian, Klingmüller, Ursula, Schultz, Carsten
Format: Online
Language:English
Published: Cell Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193178/