Early afterdepolarisation tendency as a simulated pro-arrhythmic risk indicator

by McMillan, Beth, Gavaghan, David J., Mirams, Gary R.
Published 2017

Hodgkin–Huxley revisited: reparametrization and identifiability analysis of the classic action potential model with approximate Bayesian methods

by Daly, Aidan C., Gavaghan, David J., Holmes, Chris, Cooper, Jonathan
Published 2015

Reproducible model development in the Cardiac Electrophysiology Web Lab

by Daly, Aidan C., Clerx, Michael, Beattie, Kylie A., Cooper, Jonathan, Gavaghan, David J., Mirams, Gary R.
Published 2018

Representation of multiple cellular phenotypes within tissue-level simulations of cardiac electrophysiology

by Bowler, Louise A., Gavaghan, David J., Mirams, Gary R., Whiteley, Jonathan P.
Published 2018

Hierarchical Bayesian inference for ion channel screening dose-response data

by Johnstone, Ross H., Bardenet, Rémi, Gavaghan, David J., Mirams, Gary R.
Published 2017

Pooling data for Number Needed to Treat: no problems for apples

by Moore, R Andrew, Gavaghan, David J, Edwards, Jayne E, Wiffen, Phillip, McQuay, Henry J
Published 2002

The Free Energy Landscape of Dimerization of a Membrane Protein, NanC

by Dunton, Thomas A., Goose, Joseph E., Gavaghan, David J., Sansom, Mark S. P., Osborne, James M.
Published 2014

Hierarchical Bayesian inference for ion channel screening dose-response data

by Johnstone, Ross H, Bardenet, Rémi, Gavaghan, David J, Mirams, Gary R
Published 2017

A Two-Dimensional Model of the Colonic Crypt Accounting for the Role of the Basement Membrane and Pericryptal Fibroblast Sheath

by Dunn, Sara-Jane, Appleton, Paul L., Nelson, Scott A., Näthke, Inke S., Gavaghan, David J., Osborne, James M.
Published 2012

Cardiac tissue slices: preparation, handling, and successful optical mapping

by Wang, Ken, Lee, Peter, Mirams, Gary R., Sarathchandra, Padmini, Borg, Thomas K., Gavaghan, David J., Kohl, Peter, Bollensdorff, Christian
Published 2015

Evaluation of an in silico cardiac safety assay: Using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge

by Beattie, Kylie A., Luscombe, Chris, Williams, Geoff, Munoz-Muriedas, Jordi, Gavaghan, David J., Cui, Yi, Mirams, Gary R.
Published 2013

Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment

by Elkins, Ryan C., Davies, Mark R., Brough, Stephen J., Gavaghan, David J., Cui, Yi, Abi-Gerges, Najah, Mirams, Gary R.
Published 2013

Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics

by Beattie, Kylie, Hill, Adam P., Bardenet, Rémi, Cui, Yi, Vandenberg, Jamie I., Gavaghan, David J., de Boer, Teun P., Mirams, Gary R.
Published 2018

Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk

by Mirams, Gary R., Cui, Yi, Sher, Anna, Fink, Martin, Cooper, Jonathan, Heath, Bronagh M., McMahon, Nick C., Gavaghan, David J., Noble, Denis
Published 2011

Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models?

by Johnstone, Ross H., Chang, Eugene T.Y., Bardenet, Rémi, de Boer, Teun P., Gavaghan, David J., Pathmanathan, Pras, Clayton, Richard H., Mirams, Gary R.
Published 2016

Prediction of Thorough QT study results using action potential simulations based on ion channel screens

by Mirams, Gary R., Davies, Mark R., Brough, Stephen J., Bridgland-Taylor, Matthew H., Cui, Yi, Gavaghan, David J., Abi-Gerges, Najah
Published 2014

Tailoring mathematical models to stem-cell derived cardiomyocyte lines can improve predictions of drug-induced changes to their electrophysiology

by Lei, Chon-Lok, Wang, Ken, Clerx, Michael, Johnstone, Ross H., Hortigon-Vinagre, Maria P., Zamora, Victor, Allan, Andrew, Smith, Godfrey L., Gavaghan, David J., Mirams, Gary R., Polonchuk, Liudmila
Published 2017

Ten Simple Rules for Effective Computational Research

by Osborne, James M., Bernabeu, Miguel O., Bruna, Maria, Calderhead, Ben, Cooper, Jonathan, Dalchau, Neil, Dunn, Sara-Jane, Fletcher, Alexander G., Freeman, Robin, Groen, Derek, Knapp, Bernhard, McInerny, Greg J., Mirams, Gary R., Pitt-Francis, Joe, Sengupta, Biswa, Wright, David W., Yates, Christian A., Gavaghan, David J., Emmott, Stephen, Deane, Charlotte
Published 2014

Chaste: An Open Source C++ Library for Computational Physiology and Biology

by Mirams, Gary R., Arthurs, Christopher J., Bernabeu, Miguel O., Bordas, Rafel, Cooper, Jonathan, Corrias, Alberto, Davit, Yohan, Dunn, Sara-Jane, Fletcher, Alexander G., Harvey, Daniel G., Marsh, Megan E., Osborne, James M., Pathmanathan, Pras, Pitt-Francis, Joe, Southern, James, Zemzemi, Nejib, Gavaghan, David J.
Published 2013