p21-activated kinase 1: PAK'ed with potential

by Ong, Christy C., Jubb, Adrian M., Zhou, Wei, Haverty, Peter M., Harris, Adrian L., Belvin, Marcia, Friedman, Lori S., Koeppen, Hartmut, Hoeflich, Klaus P.
Published 2011

Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis

by Soler, Adriana, Serra, Helena, Pearce, Wayne, Angulo, Ana, Guillermet-Guibert, Julie, Friedman, Lori S., Viñals, Francesc, Gerhardt, Holger, Casanovas, Oriol, Graupera, Mariona, Vanhaesebroeck, Bart
Published 2013

The PI3K inhibitor taselisib overcomes letrozole resistance in a breast cancer model expressing aromatase

by Hoeflich, Klaus P., Guan, Jane, Edgar, Kyle A., O'Brien, Carol, Savage, Heidi, Wilson, Timothy R., Neve, Richard M., Friedman, Lori S., Wallin, Jeffrey J.
Published 2016

Targeting the PI3K/Akt pathway in murine MDS/MPN driven by hyperactive Ras

by Akutagawa, Jon, Huang, Tannie Q., Epstein, Inbal, Chang, Tiffany, Quirindongo-Crespo, Maricel, Cottonham, Charisa L., Dail, Monique, Slusher, Barbara S., Friedman, Lori S., Sampath, Deepak, Braun, Benjamin S.
Published 2016

Inactivation of the PI3K p110δ breaks regulatory T cell-mediated immune tolerance to cancer

by Ali, Khaled, Soond, Dalya R., Pineiro, Roberto, Hagemann, Thorsten, Pearce, Wayne, Lim, Ee Lyn, Bouabe, Hicham, Scudamore, Cheryl L., Hancox, Timothy, Maecker, Heather, Friedman, Lori, Turner, Martin, Okkenhaug, Klaus, Vanhaesebroeck, Bart
Published 2014

Amphiregulin and PTEN evoke a multimodal mechanism of acquired resistance to PI3K inhibition

by Edgar, Kyle A., Crocker, Lisa, Cheng, Eric, Wagle, Marie-Claire, Wongchenko, Matthew, Yan, Yibing, Wilson, Timothy R., Dompe, Nicholas, Neve, Richard M., Belvin, Marcia, Sampath, Deepak, Friedman, Lori S., Wallin, Jeffrey J.
Published 2014

Active PI3K Pathway Causes an Invasive Phenotype Which Can Be Reversed or Promoted by Blocking the Pathway at Divergent Nodes

by Wallin, Jeffrey J., Guan, Jane, Edgar, Kyle A., Zhou, Wei, Francis, Ross, Torres, Anthony C., Haverty, Peter M., Eastham-Anderson, Jeffrey, Arena, Sabrina, Bardelli, Alberto, Griffin, Sue, Goodall, John E., Grimshaw, Kyla M., Hoeflich, Klaus P., Torrance, Christopher, Belvin, Marcia, Friedman, Lori S.
Published 2012

Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents

by Ong, Christy C, Gierke, Sarah, Pitt, Cameron, Sagolla, Meredith, Cheng, Christine K, Zhou, Wei, Jubb, Adrian M, Strickland, Laura, Schmidt, Maike, Duron, Sergio G, Campbell, David A, Zheng, Wei, Dehdashti, Seameen, Shen, Min, Yang, Nora, Behnke, Mark L, Huang, Wenwei, McKew, John C, Chernoff, Jonathan, Forrest, William F, Haverty, Peter M, Chin, Suet-Feung, Rakha, Emad A, Green, Andrew R, Ellis, Ian O, Caldas, Carlos, O’Brien, Thomas, Friedman, Lori S, Koeppen, Hartmut, Rudolph, Joachim, Hoeflich, Klaus P
Published 2015

The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer

by Joseph, James D, Darimont, Beatrice, Zhou, Wei, Arrazate, Alfonso, Young, Amy, Ingalla, Ellen, Walter, Kimberly, Blake, Robert A, Nonomiya, Jim, Guan, Zhengyu, Kategaya, Lorna, Govek, Steven P, Lai, Andiliy G, Kahraman, Mehmet, Brigham, Dan, Sensintaffar, John, Lu, Nhin, Shao, Gang, Qian, Jing, Grillot, Kate, Moon, Michael, Prudente, Rene, Bischoff, Eric, Lee, Kyoung-Jin, Bonnefous, Celine, Douglas, Karensa L, Julien, Jackaline D, Nagasawa, Johnny Y, Aparicio, Anna, Kaufman, Josh, Haley, Benjamin, Giltnane, Jennifer M, Wertz, Ingrid E, Lackner, Mark R, Nannini, Michelle A, Sampath, Deepak, Schwarz, Luis, Manning, Henry Charles, Tantawy, Mohammed Noor, Arteaga, Carlos L, Heyman, Richard A, Rix, Peter J, Friedman, Lori, Smith, Nicholas D, Metcalfe, Ciara, Hager, Jeffrey H
Published 2016