Squamous Metaplasia Is Increased in the Bronchial Epithelium of Smokers with Chronic Obstructive Pulmonary Disease

by Rigden, Helen M., Alias, Ahmad, Havelock, Thomas, O'Donnell, Rory, Djukanovic, Ratko, Davies, Donna E., Wilson, Susan J.
Published 2016

EGF-Induced Bronchial Epithelial Cells Drive Neutrophil Chemotactic and Anti-Apoptotic Activity in Asthma

by Uddin, Mohib, Lau, Laurie C., Seumois, Grégory, Vijayanand, Pandurangan, Staples, Karl J., Bagmane, Dinesh, Cornelius, Victoria, Dorinsky, Paul, Davies, Donna E., Djukanović, Ratko
Published 2013

Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study

by Loza, Matthew J., Djukanovic, Ratko, Chung, Kian Fan, Horowitz, Daniel, Ma, Keying, Branigan, Patrick, Barnathan, Elliot S., Susulic, Vedrana S., Silkoff, Philip E., Sterk, Peter J., Baribaud, Frédéric
Published 2016

Viral Infection of Human Lung Macrophages Increases PDL1 Expression via IFNβ

by Staples, Karl J., Nicholas, Ben, McKendry, Richard T., Spalluto, C. Mirella, Wallington, Joshua C., Bragg, Craig W., Robinson, Emily C., Martin, Kirstin, Djukanović, Ratko, Wilkinson, Tom M. A.
Published 2015

Innate and adaptive T cells in asthmatic patients: Relationship to severity and disease mechanisms

by Hinks, Timothy S.C., Zhou, Xiaoying, Staples, Karl J., Dimitrov, Borislav D., Manta, Alexander, Petrossian, Tanya, Lum, Pek Y., Smith, Caroline G., Ward, Jon A., Howarth, Peter H., Walls, Andrew F., Gadola, Stephan D., Djukanović, Ratko
Published 2015

Viral Inhibition of Bacterial Phagocytosis by Human Macrophages: Redundant Role of CD36

by Cooper, Grace E., Pounce, Zoe C., Wallington, Joshua C., Bastidas-Legarda, Leidy Y., Nicholas, Ben, Chidomere, Chiamaka, Robinson, Emily C., Martin, Kirstin, Tocheva, Anna S., Christodoulides, Myron, Djukanovic, Ratko, Wilkinson, Tom M. A., Staples, Karl J.
Published 2016

A Novel Lung Explant Model for the Ex Vivo Study of Efficacy and Mechanisms of Anti-Influenza Drugs

by Nicholas, Ben, Staples, Karl J., Moese, Stefan, Meldrum, Eric, Ward, Jon, Dennison, Patrick, Havelock, Tom, Hinks, Timothy S. C., Amer, Khalid, Woo, Edwin, Chamberlain, Martin, Singh, Neeta, North, Malcolm, Pink, Sandy, Wilkinson, Tom M. A., Djukanović, Ratko
Published 2015

Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3–like protein 1

by Hinks, Timothy S.C., Brown, Tom, Lau, Laurie C.K., Rupani, Hitasha, Barber, Clair, Elliott, Scott, Ward, Jon A., Ono, Junya, Ohta, Shoichiro, Izuhara, Kenji, Djukanović, Ratko, Kurukulaaratchy, Ramesh J., Chauhan, Anoop, Howarth, Peter H.
Published 2016

Severe asthma exists despite suppressed tissue inflammation: findings of the U-BIOPRED study

by Wilson, Susan J., Ward, Jonathan A., Sousa, Ana R., Corfield, Julie, Bansal, Aruna T., De Meulder, Bertrand, Lefaudeux, Diane, Auffray, Charles, Loza, Matthew J., Baribaud, Frederic, Fitch, Neil, Sterk, Peter J., Chung, Kian Fan, Gibeon, David, Sun, Kai, Guo, Yi-ke, Adcock, Ian M., Djukanovic, Ratko, Dahlen, Barbro, Chanez, Pascal, Shaw, Dominick E., Krug, Norbert, Hohlfeld, Jens, Sandström, Thomas, Howarth, Peter H.
Published 2016

Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: an exploratory analysis

by Takahashi, Kentaro, Pavlidis, Stelios, Ng Kee Kwong, Francois, Hoda, Uruj, Rossios, Christos, Sun, Kai, Loza, Matthew, Baribaud, Fred, Chanez, Pascal, Fowler, Steve J., Horvath, Ildiko, Montuschi, Paolo, Singer, Florian, Musial, Jacek, Dahlen, Barbro, Dahlen, Sven-Eric, Krug, Norbert, Sandstrom, Thomas, Shaw, Dominic E., Lutter, Rene, Bakke, Per, Fleming, Louise J., Howarth, Peter H., Caruso, Massimo, Sousa, Ana R., Corfield, Julie, Auffray, Charles, De Meulder, Bertrand, Lefaudeux, Diane, Djukanovic, Ratko, Sterk, Peter J., Guo, Yike, Adcock, Ian M., Chung, Kian Fan
Published 2018

A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protoco...

by Hanratty, Catherine E., Matthews, John G., Arron, Joseph R., Choy, David F., Pavord, Ian D., Bradding, P., Brightling, Christopher E., Chaudhuri, Rekha, Cowan, Douglas C., Djukanovic, Ratko, Gallagher, Nicola, Fowler, Stephen J., Hardman, Tim C., Harrison, Tim, Holweg, Cécile T., Howarth, Peter H., Lordan, James, Mansur, Adel H., Menzies-Gow, Andrew, Mosesova, Sofia, Niven, Robert M., Robinson, Douglas S., Shaw, Dominick E., Walker, Samantha, Woodcock, Ashley, Heaney, Liam G.
Published 2018

Transcriptomic gene signatures associated with persistent airflow limitation in patients with severe asthma

by Hekking, Pieter-Paul, Loza, Matthew J., Pavlidis, Stelios, De Meulder, Bertrand, Lefaudeux, Diane, Baribaud, Frederic, Auffray, Charles, Wagener, Ariane H., Brinkman, Paul, Lutter, René, Bansal, Aruna T., Sousa, Ana R., Bates, Stewart A., Pandis, Ioannis, Fleming, Louise J., Shaw, Dominick E., Fowler, Stephen J., Guo, Yike, Meiser, Andrea, Sun, Kai, Corfield, Julie, Howarth, Peter, Bel, Elisabeth H., Adcock, Ian M., Chung, Kian Fan, Djukanovic, Ratko, Sterk, Peter J.
Published 2017

Pathway discovery using transcriptomic profiles in adult-onset severe asthma

by Hekking, Pieter-Paul, Loza, Matt J., Pavlidis, Stelios, de Meulder, Bertrand, Lefaudeux, Diane, Baribaud, Fred, Auffray, Charles, Wagener, Ariane H., Brinkman, Paul, Lutter, Rene, Bansal, Aruna T., Sousa, Ana R., Bates, Steve A., Pandis, Yannis, Fleming, Louise J., Shaw, Dominique E., Fowler, Stephen J., Guo, Y., Meiser, Andrea, Sun, Kai, Corfield, Julie, Howarth, Peter H., Bel, Elisabeth H., Adcock, Ian M., Chung, Kian Fan, Djukanovic, Ratko, Sterk, Peter J.
Published 2018

U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics

by Lefaudeux, Diane, De Meulder, Bertrand, Loza, Matthew J., Peffer, Nancy, Rowe, Anthony, Baribaud, Frédéric, Bansal, Aruna T., Lutter, Rene, Sousa, Ana R., Corfield, Julie, Pandis, Ioannis, Bakke, Per S., Caruso, Massimo, Chanez, Pascal, Dahlén, Sven-Erik, Fleming, Louise J., Fowler, Stephen J., Horvath, Ildiko, Krug, Norbert, Montuschi, Paolo, Sanak, Marek, Sandstrom, Thomas, Shaw, Dominic E., Singer, Florian, Sterk, Peter J., Roberts, Graham, Adcock, Ian M., Djukanovic, Ratko, Auffray, Charles, Chung, Kian Fan
Published 2017

A transcriptome-driven analysis of epithelial brushings and bronchial biopsies to define asthma phenotypes in U-BIOPRED

by Khuo, Chih-Hsi Scott, Pavlidis, Stelios, Loza, Matthew, Baribaud, Fred, Rowe, Anthony, Pandis, Ioannis, Hoda, Uruj, Rossios, Christos, Sousa, Ana, Wilson, Susan J., Howarth, Peter, Dahlen, Barbro, Dahlen, Sven-Erik, Chanez, Pascal, Shaw, Dominick E., Krug, Norbert, Sandström, Thomas, De Meulder, Betrand, Lefaudeux, Diane, Fowler, Stephen, Fleming, Louise, Corfield, Julie, Auffray, Charles, Sterk, Peter J., Djukanovic, Ratko, Guo, Yike, Adcock, Ian M., Chung, Kian Fan
Published 2016

Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK)

by Heaney, Liam G, Djukanovic, Ratko, Woodcock, Ashley, Walker, Samantha, Matthews, John G, Pavord, Ian D, Bradding, Peter, Niven, Robert, Brightling, Chris E, Chaudhuri, Rekha, Arron, Joseph R, Choy, David F, Cowan, Douglas, Mansur, Adel, Menzies-Gow, Andrew, Adcock, Ian, Chung, Kian F, Corrigan, Chris, Coyle, Peter, Harrison, Timothy, Johnston, Sebastian, Howarth, Peter, Lordan, James, Sabroe, Ian, Bigler, Jeannette, Smith, Dirk, Catley, Matthew, May, Richard, Pierre, Lisa, Stevenson, Chris, Crater, Glenn, Keane, Frank, Costello, Richard W, Hudson, Val, Supple, David, Hardman, Tim
Published 2016

Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation

by Jevnikar, Zala, Östling, Jörgen, Ax, Elisabeth, Calvén, Jenny, Thörn, Kristofer, Israelsson, Elisabeth, Öberg, Lisa, Singhania, Akul, Lau, Laurie C.K., Wilson, Susan J., Ward, Jonathan A., Chauhan, Anoop, Sousa, Ana R., De Meulder, Bertrand, Loza, Matthew J., Baribaud, Frédéric, Sterk, Peter J., Chung, Kian Fan, Sun, Kai, Guo, Yike, Adcock, Ian M., Payne, Debbie, Dahlen, Barbro, Chanez, Pascal, Shaw, Dominick E., Krug, Norbert, Hohlfeld, Jens M., Sandström, Thomas, Djukanovic, Ratko, James, Anna, Hinks, Timothy S.C., Howarth, Peter H., Vaarala, Outi, van Geest, Marleen, Olsson, Henric K.
Published 2018

Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort

by Shaw, Dominick E., Sousa, Ana R., Fowler, Stephen J., Fleming, Louise J., Roberts, Graham, Corfield, Julie, Pandis, Ioannis, Bansal, Aruna T., Bel, Elisabeth H., Auffray, Charles, Compton, Chris H., Bisgaard, Hans, Bucchioni, Enrica, Caruso, Massimo, Chanez, Pascal, Dahlen, Barbro, Dahlen, Sven-Erik, Dyson, Kerry, Frey, Urs, Geiser, Thomas, Gerhardsson de Verdier, Maria, Gibeon, David, Guo, Yi-ke, Hashimoto, Simone, Hedlin, Gunilla, Jeyasingham, Elizabeth, Hekking, Pieter-Paul W., Higenbottam, Tim, Horváth, Ildikó, Knox, Alan J., Krug, Norbert, Erpenbeck, Veit J., Larsson, Lars X., Lazarinis, Nikos, Matthews, John G., Middelveld, Roelinde, Montuschi, Paolo, Musial, Jacek, Myles, David, Pahus, Laurie, Sandström, Thomas, Seibold, Wolfgang, Singer, Florian, Strandberg, Karin, Vestbo, Jorgen, Vissing, Nadja, von Garnier, Christophe, Adcock, Ian M., Wagers, Scott, Rowe, Anthony, Howarth, Peter, Wagener, Ariane H., Djukanovic, Ratko, Sterk, Peter J., Chung, Kian Fan
Published 2015