A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial

Background: Patients with difficult-to-control asthma consume 50–60% of healthcare costs attributed to asthma and cost approximately five-times more than patients with mild stable disease. Recent evidence demonstrates that not all patients with asthma have a typical type 2 (T2)-driven eosinophilic i...

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Main Authors:	Hanratty, Catherine E., Matthews, John G., Arron, Joseph R., Choy, David F., Pavord, Ian D., Bradding, P., Brightling, Christopher E., Chaudhuri, Rekha, Cowan, Douglas C., Djukanovic, Ratko, Gallagher, Nicola, Fowler, Stephen J., Hardman, Tim C., Harrison, Tim, Holweg, Cécile T., Howarth, Peter H., Lordan, James, Mansur, Adel H., Menzies-Gow, Andrew, Mosesova, Sofia, Niven, Robert M., Robinson, Douglas S., Shaw, Dominick E., Walker, Samantha, Woodcock, Ashley, Heaney, Liam G.
Format:	Article
Language:	English
Published:	BioMed Central 2018
Online Access:	http://eprints.nottingham.ac.uk/51850/ http://eprints.nottingham.ac.uk/51850/ http://eprints.nottingham.ac.uk/51850/ http://eprints.nottingham.ac.uk/51850/1/document_17.05.2018.pdf

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http://eprints.nottingham.ac.uk/51850/
http://eprints.nottingham.ac.uk/51850/
http://eprints.nottingham.ac.uk/51850/
http://eprints.nottingham.ac.uk/51850/1/document_17.05.2018.pdf

A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial

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