PD-1 and BTLA and CD8+ T-cell “exhaustion” in cancer: “Exercising” an alternative viewpoint

by Haymaker, Cara, Wu, Richard, Bernatchez, Chantale, Radvanyi, Laszlo
Published 2012

Modification of BTLA signaling motifs in TIL exhibits positive signals that mediate anti-tumor control

by Ritthipichai, Krit, Haymaker, Cara, Hailemichael, Yared, Zhang, Minying, Nurieva, Roza, Hwu, Patrick, Bernatchez, Chantale
Published 2015

You can run but you can't hide: tracking T cells in metastatic melanoma patients treated with tumor-infiltrating lymphocytes

by Haymaker, Cara, Forget, Marie-Andrée, Creasy, Caitlin, Ritthipichai, Krit, Hwu, Patrick, Bernatchez, Chantale
Published 2015

Preclinical development of tumor-infiltrating lymphocyte therapy for ovarian cancer

by Sakellariou-Thompson, Donastas, Haymaker, Cara, Forget, Marie-Andree, Jazaeri, Amir, Hwu, Patrick, Bernatchez, Chantale
Published 2015

Immune-Modulation by Epidermal Growth Factor Receptor Inhibitors: Implication on Anti-Tumor Immunity in Lung Cancer

by Im, Jin S., Herrmann, Amanda C., Bernatchez, Chantale, Haymaker, Cara, Molldrem, Jeffrey J., Hong, Waun Ki, Perez-Soler, Roman
Published 2016

Single-cell motility and gene expression signature as predictors of the overall survival of act in melanoma patients

by Martinez-Paniagua, Melisa, Haymaker, Cara, Adolacion, Jay R, Radvanyi, Laszlo, Hwu, Patrick, Roysam, Badrinath, Bernatchez, Chantale, Varadarajan, Navin
Published 2015

Prognostic and biologic significance of high LCK expression in ovarian cancer

by Jazaeri, Amir, Paquette, Cherie, Kelting, Sarah M, Stoler, Mark H, Zhang, Qian, Yates, Melinda, Creasy, Caitlin, Bernatchez, Chantale, Hwu, Patrick
Published 2015

Uncovering a novel function of BTLA on tumor-infiltrating CD8+ T cells

by Haymaker, Cara, Wu, Richard, Ritthipichai, Krit, Bernatchez, Chantale, Forget, Marie-Andree, Chen, Jie Qing, Liu, Hiu, Wang, Ena, Marincola, Francesco, Hwu, Patrick, Radvanyi, Laszlo
Published 2013

Development of novel combinations of targeted and immunotherapies by understanding immune resistance using a high throughput assay of T cell mediated cytotoxicity

by Malu, Shruti, Mbofung, Rina, Khalili, Jahan, Satani, Nikunj, Forget, Marie-Andrée, Haymaker, Cara, Muller, Florian, Bernatchez, Chantale, Radvanyi, Laszlo, Hwu, Patrick
Published 2013

Genetically modified artificial antigen-presenting cells (aAPC) for expansion of melanoma tumor infiltrating lymphocytes with optimal properties for adoptive cell therapy

by Forget, Marie-Andrée, Malu, Shruti, Liu, Hiu, Toth, Christopher, Maiti, Sourindra, Kale, Charuta, Bernatchez, Chantale, Huls, Helen, Wang, Ena, Hwu, Patrick, Cooper, Laurence J, Radvanyi, Laszlo G
Published 2013

Identification of predictive biomarker signatures in melanoma tumors associated with response to tumor-infiltrating lymphocyte (TIL) therapy

by Chen, Jie Qing, Creasy, Caitlin, Cabala, Carlos Antonio Torres, Ekmekcioglu, Suhendan, Maiti, Sourindra N, Roszik, Jason, Haymaker, Cara, Bernatchez, Chantale, Hwu, Patrick, Radvanyi, Laszlo
Published 2013

A case report of Grover’s disease from immunotherapy-a skin toxicity induced by inhibition of CTLA-4 but not PD-1

by Uemura, Marc, Faisal, Faa’k, Haymaker, Cara, McQuail, Natalie, Sirmans, Elizabeth, Hudgens, Courtney W., Barbara, Lydia, Bernatchez, Chantale, Curry, Jonathan L., Hwu, Patrick, Tetzlaff, Michael T., Diab, Adi
Published 2016

Selective inhibition of autoimmune exacerbation while preserving the anti-tumor clinical benefit using IL-6 blockade in a patient with advanced melanoma and Crohn’s disease: a case...

by Uemura, Marc, Trinh, Van A., Haymaker, Cara, Jackson, Natalie, Kim, Dae Won, Allison, James P., Sharma, Padmanee, Vence, Luis, Bernatchez, Chantale, Hwu, Patrick, Diab, Adi
Published 2016

BTLA marks a less-differentiated tumor-infiltrating lymphocyte subset in melanoma with enhanced survival properties

by Haymaker, Cara L, Wu, Richard C, Ritthipichai, Krit, Bernatchez, Chantale, Forget, Marie-Andrée, Chen, Jie Qing, Liu, Hui, Wang, Ena, Marincola, Francesco, Hwu, Patrick, Radvanyi, Laszlo G
Published 2015

The beneficial effects of a gas-permeable flask for expansion of Tumor-Infiltrating lymphocytes as reflected in their mitochondrial function and respiration capacity

by Forget, Marie-Andrée, Haymaker, Cara, Dennison, Jennifer B, Toth, Christopher, Maiti, Sourindra, Fulbright, Orenthial J, Cooper, Laurence J N, Hwu, Patrick, Radvanyi, Laszlo G, Bernatchez, Chantale
Published 2015

Intra-patient intra-tumoral immune heterogeneity is evident at progression on targeted therapy and immunotherapy for melanoma

by Reuben, Alexandre, Cooper, Zachary A, Amaria, Rodabe N, Forget, Marie A, Haymaker, Cara, Bernatchez, Chantale, Chen, Pei-ling, Tetzlaff, Michael T, Chin, Lynda, Dwyer, Karen C, Wargo, Jennifer A
Published 2014

Predictive immune biomarker signatures in the tumor microenvironment of melanoma metastases associated with tumor-infiltrating lymphocyte (TIL) therapy

by Chen, Jieqing, Creasy, Caitlin, Torres-Cabala, Carlos Antonio, Ekmekcioglu, Suhendan, Maiti, Sourindra N, Kale, Charuta, Haymaker, Cara, Roszik, Jason, Bassett, Roland L, Hu, Jianhua, Wang, Zhiqiang, Ma, Wencai, Davis, R Eric, Bernatchez, Chantale, Hwu, Patrick, Radvanyi, Laszlo
Published 2014

Molecular and immune heterogeneity in synchronous melanoma metastases

by Reuben, Alexandre, Spencer, Christine, Roszik, Jason, Miller, John, Kwong, Lawrence, Jiang, Hong, Haymaker, Cara, Chen, Pei-Ling, Austin-Breneman, Jacob, Roh, Whijae, Little, Latasha, Cao, Yu, Garber, Haven, Forget, Marie-Andrée, Gopalakrishnan, Vancheswaran, Amaria, Rodabe, Davies, Michael, Bernatchez, Chantale, Roger, Edwin, Cuentas, Parra, Rodriguez, Jaime, Tetzlaff, Michael, Woodman, Scott, Dwyer, Karen, Sharma, Padmanee, Allison, James, Chin, Lynda, Futreal, Andrew, Cooper, Zachary, Wargo, Jennifer
Published 2015

Pilot study of intratumoral (IT) cryoablation (cryo) in combination with systemic checkpoint blockade in patients with metastatic melanoma (MM)

by Kim, Dae Won, Haymaker, Cara, McQuail, Natalie, Sirmans, Elizabeth, Spencer, Christine, Glitza, Isabella, Amaria, Rodabe, Woodman, Scott, Patel, Sapna, Davies, Michael, Yee, Cassian, Hwu, Wen-Jen, Bernatchez, Chantale, Wargo, Jennifer, Sharma, Padmanee, Allison, James, Hwu, Patrick, Tam, Alda, Diab, Adi
Published 2015

Novel algorithmic approach predicts tumor mutation load and correlates with immunotherapy clinical outcomes using a defined gene mutation set

by Roszik, Jason, Haydu, Lauren E., Hess, Kenneth R., Oba, Junna, Joon, Aron Y., Siroy, Alan E., Karpinets, Tatiana V., Stingo, Francesco C., Baladandayuthapani, Veera, Tetzlaff, Michael T., Wargo, Jennifer A., Chen, Ken, Forget, Marie-Andrée, Haymaker, Cara L., Chen, Jie Qing, Meric-Bernstam, Funda, Eterovic, Agda K., Shaw, Kenna R., Mills, Gordon B., Gershenwald, Jeffrey E., Radvanyi, Laszlo G., Hwu, Patrick, Futreal, P. Andrew, Gibbons, Don L., Lazar, Alexander J., Bernatchez, Chantale, Davies, Michael A., Woodman, Scott E.
Published 2016