PD-1 and BTLA and CD8+ T-cell “exhaustion” in cancer: “Exercising” an alternative viewpoint

by Haymaker, Cara, Wu, Richard, Bernatchez, Chantale, Radvanyi, Laszlo
Published 2012

New insights on the role of CD8+CD57+ T-cells in cancer

by Wu, Richard C., Hwu, Patrick, Radvanyi, Laszlo G.
Published 2012

Continuous 4–1BB co-stimulatory signals for the optimal expansion of tumor-infiltrating lymphocytes for adoptive T-cell therapy

by Chacon, Jessica Ann, Pilon-Thomas, Shari, Sarnaik, Amod A, Radvanyi, Laszlo G
Published 2013

Immediate triggering of 4-1BB co-stimulation during initiation of tumor-infiltrating lymphocyte (TIL) expansion from melanoma tumors accelerates CD8+ T-cell outgrowth and tumor spe...

by Chacon, Jessica, Pilon-Thomas, Shari, Sarnaik, Amod, Hwu, Patrick, Radvanyi, Laszlo
Published 2013

IL-2 analogues: novel agents circumventing the expansion of T regulatory cells while promoting NK cell activation during IL-2 therapy

by Sim, Geok Choo, Grimm, Elizabeth, Dai, ZhiMin, Overwijk, Willem, Hwu, Patrick, Radvanyi, Laszlo
Published 2013

Defective STAT1 activation associated with impaired IFN-γ production in NK and T lymphocytes from metastatic melanoma patients treated with IL-2

by Sim, Geok Choo, Wu, Sheng, Jin, Lei, Hwu, Patrick, Radvanyi, Laszlo G.
Published 2016

Single-cell motility and gene expression signature as predictors of the overall survival of act in melanoma patients

by Martinez-Paniagua, Melisa, Haymaker, Cara, Adolacion, Jay R, Radvanyi, Laszlo, Hwu, Patrick, Roysam, Badrinath, Bernatchez, Chantale, Varadarajan, Navin
Published 2015

Co-Stimulation through 4-1BB/CD137 Improves the Expansion and Function of CD8+ Melanoma Tumor-Infiltrating Lymphocytes for Adoptive T-Cell Therapy

by Chacon, Jessica Ann, Wu, Richard C., Sukhumalchandra, Pariya, Molldrem, Jeffrey J., Sarnaik, Amod, Pilon-Thomas, Shari, Weber, Jeffrey, Hwu, Patrick, Radvanyi, Laszlo
Published 2013

Uncovering a novel function of BTLA on tumor-infiltrating CD8+ T cells

by Haymaker, Cara, Wu, Richard, Ritthipichai, Krit, Bernatchez, Chantale, Forget, Marie-Andree, Chen, Jie Qing, Liu, Hiu, Wang, Ena, Marincola, Francesco, Hwu, Patrick, Radvanyi, Laszlo
Published 2013

Development of novel combinations of targeted and immunotherapies by understanding immune resistance using a high throughput assay of T cell mediated cytotoxicity

by Malu, Shruti, Mbofung, Rina, Khalili, Jahan, Satani, Nikunj, Forget, Marie-Andrée, Haymaker, Cara, Muller, Florian, Bernatchez, Chantale, Radvanyi, Laszlo, Hwu, Patrick
Published 2013

Genetically modified artificial antigen-presenting cells (aAPC) for expansion of melanoma tumor infiltrating lymphocytes with optimal properties for adoptive cell therapy

by Forget, Marie-Andrée, Malu, Shruti, Liu, Hiu, Toth, Christopher, Maiti, Sourindra, Kale, Charuta, Bernatchez, Chantale, Huls, Helen, Wang, Ena, Hwu, Patrick, Cooper, Laurence J, Radvanyi, Laszlo G
Published 2013

Identification of predictive biomarker signatures in melanoma tumors associated with response to tumor-infiltrating lymphocyte (TIL) therapy

by Chen, Jie Qing, Creasy, Caitlin, Cabala, Carlos Antonio Torres, Ekmekcioglu, Suhendan, Maiti, Sourindra N, Roszik, Jason, Haymaker, Cara, Bernatchez, Chantale, Hwu, Patrick, Radvanyi, Laszlo
Published 2013

BTLA marks a less-differentiated tumor-infiltrating lymphocyte subset in melanoma with enhanced survival properties

by Haymaker, Cara L, Wu, Richard C, Ritthipichai, Krit, Bernatchez, Chantale, Forget, Marie-Andrée, Chen, Jie Qing, Liu, Hui, Wang, Ena, Marincola, Francesco, Hwu, Patrick, Radvanyi, Laszlo G
Published 2015

The beneficial effects of a gas-permeable flask for expansion of Tumor-Infiltrating lymphocytes as reflected in their mitochondrial function and respiration capacity

by Forget, Marie-Andrée, Haymaker, Cara, Dennison, Jennifer B, Toth, Christopher, Maiti, Sourindra, Fulbright, Orenthial J, Cooper, Laurence J N, Hwu, Patrick, Radvanyi, Laszlo G, Bernatchez, Chantale
Published 2015

Depressive Symptoms and Cortisol Rhythmicity Predict Survival in Patients with Renal Cell Carcinoma: Role of Inflammatory Signaling

by Cohen, Lorenzo, Cole, Steven W., Sood, Anil K., Prinsloo, Sarah, Kirschbaum, Clemens, Arevalo, Jesusa M. G., Jennings, Nicholas B., Scott, Shellie, Vence, Luis, Wei, Qi, Kentor, Diane, Radvanyi, Laszlo, Tannir, Nizar, Jonasch, Eric, Tamboli, Pheroze, Pisters, Louis
Published 2012

An Antibody-based Blood Test Utilizing a Panel of Biomarkers as a New Method for Improved Breast Cancer Diagnosis

by Yahalom, Galit, Weiss, Daria, Novikov, Ilya, Bevers, Therese B., Radvanyi, Laszlo G., Liu, Mei, Piura, Benjamin, Iacobelli, Stefano, Sandri, Maria T., Cassano, Enrico, Allweis, Tanir M., Bitterman, Arie, Engelman, Pnina, Vence, Luis M., Rosenberg, Marvin M.
Published 2013

Target discovery for T cell therapy: next steps to advance Immunotherapies

by Bot, Adrian, Brewer, Joanna E, Eshhar, Zelig, Frankel, Stanley R, Hickman, Emma, Jungbluth, Achim A, Morgan, Richard, Peretz, Yoav, Radvanyi, Laszlo, Ramos, Carlos A, Robbins, Paul F, Wucherpfennig, Kai W
Published 2015

Analysis of the Intratumoral Adaptive Immune Response in Well Differentiated and Dedifferentiated Retroperitoneal Liposarcoma

by Tseng, William W., Malu, Shruti, Zhang, Minying, Chen, Jieqing, Sim, Geok Choo, Wei, Wei, Ingram, Davis, Somaiah, Neeta, Lev, Dina C., Pollock, Raphael E., Lizée, Gregory, Radvanyi, Laszlo, Hwu, Patrick
Published 2015

Predictive immune biomarker signatures in the tumor microenvironment of melanoma metastases associated with tumor-infiltrating lymphocyte (TIL) therapy

by Chen, Jieqing, Creasy, Caitlin, Torres-Cabala, Carlos Antonio, Ekmekcioglu, Suhendan, Maiti, Sourindra N, Kale, Charuta, Haymaker, Cara, Roszik, Jason, Bassett, Roland L, Hu, Jianhua, Wang, Zhiqiang, Ma, Wencai, Davis, R Eric, Bernatchez, Chantale, Hwu, Patrick, Radvanyi, Laszlo
Published 2014

MUC1 glycopeptide epitopes predicted by computational glycomics

by SONG, WEI, DELYRIA, ELIZABETH S., CHEN, JIEQING, HUANG, WEI, LEE, JUN SOO, MITTENDORF, ELIZABETH A., IBRAHIM, NUHAD, RADVANYI, LASZLO G., LI, YUNSEN, LU, HONGZHOU, XU, HUAXI, SHI, YINQIANG, WANG, LAI-XI, ROSS, JEREMY A., RODRIGUES, SILAS P., ALMEIDA, IGOR C., YANG, XIFENG, QU, JIN, SCHOCKER, NATHANIEL S., MICHAEL, KATJA, ZHOU, DAPENG
Published 2012