A link between NMDA receptor hypofunction and GABAergic inhibition in the modulation of cognition: a comparison of neural and cognitive changes in rat models of NMDA receptor hypofunction and of prefrontal and hippocampal neural disinhibition

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A link between NMDA receptor hypofunction and GABAergic inhibition in the modulation of cognition: a comparison of neural and cognitive changes in rat models of NMDA receptor hypofunction and of prefrontal and hippocampal neural disinhibition

NMDA receptor (NMDAR) hypofunction and impaired GABAergic inhibition, so-called neural disinhibition, in the hippocampus and prefrontal cortex, have both been implicated in the pathophysiology of schizophrenia. Moreover, it has been suggested that NMDAR hypofunction and neural disinhibition are mech...

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Bibliographic Details
Main Author:	Taylor, Charlotte
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2024
Subjects:	Neural disinhibition GABA NMDA receptor hypofunction Hippocampus Prefrontal cortex Cognition Schizophrenia
Online Access:	https://eprints.nottingham.ac.uk/77029/

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