Selective inhibition of tropomyosin-receptor-kinase A (TrkA) reduces pain and joint damage in two rat models of inflammatory arthritis

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Selective inhibition of tropomyosin-receptor-kinase A (TrkA) reduces pain and joint damage in two rat models of inflammatory arthritis

Background: Inflammation is an essential component of arthritis pain. Nerve growth factor (NGF) plays a key role in acute and chronic pain states especially those associated with inflammation. NGF acts through tropomyosin-receptor-kinase A (TrkA). NGF blockade has reduced arthritis pain in clinical...

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Bibliographic Details
Main Authors:	Ashraf, Sadaf, Bouhana, Karyn S., Pheneger, Jed, Andrews, Steven W., Walsh, David A.
Format:	Article
Published:	BioMed Central Ltd 2016
Subjects:	PainInflammation ; Nerve growth factor ; Tropomyosin-receptor-kinase A ; Carrageenan ; Knee ; Collagen-induced arthritis
Online Access:	https://eprints.nottingham.ac.uk/51914/

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