Comparison of gene transfection and cytotoxicity mechanisms of linear poly(amidoamine) and branched poly(ethyleneimine) polyplexes

QR Code

Comparison of gene transfection and cytotoxicity mechanisms of linear poly(amidoamine) and branched poly(ethyleneimine) polyplexes

Purpose: This study aimed to further explore the mechanisms behind the ability of certain linear polyamidoamines (PAAs) to transfect cells with minimal cytotoxicity. Methods: The transfection efficiency of DNA complexed with a PAA of a molecular weight over 10 kDa or 25 kDa branched polyethyleneim...

Full description

Bibliographic Details
Main Authors:	Almulathanon, Ammar A.Y., Ranucci, Elisabetta, Ferruti, Paolo, Garnett, Martin C., Bosquillon, Cynthia
Format:	Article
Published:	Springer 2018
Subjects:	Gene delivery; cationic polymers; DNA-complexes; linear polyamidoamines; cytotoxicity
Online Access:	https://eprints.nottingham.ac.uk/49838/

Similar Items

Efficacy and toxicity of linear polyamidoamine polymers used in gene delivery
by: Almulathanon, Ammar
Published: (2018)

Electrochemistry of Non-Redox-Active Poly(propylenimine) and Poly(amidoamine) Dendrimers at Liquid-Liquid Interfaces
by: Berduque, A., et al.
Published: (2007)

Development and application of a linear polyamidoamine-SiRNA delivery system
by: Fathi, Zainab H
Published: (2018)

Removal of methyl orange and methylene blue from aqueous solution using dragon fruit foliage
by: Haddadian, Zahra
Published: (2012)

Characterisation and Intercellular Mechanistic Analysis of Supramolecular, Cationic, mRNA-Loaded Polyplexes for Efficient Transfection in HEK293T and A549 Cells
by: Smith, Silvia
Published: (2023)

Highly effective and CO-tolerant PtRu electrocatalysts supported on poly(ethyleneimine) functionalized carbon nanotubes for direct methanol fuel cells
by: Cheng, Y., et al.
Published: (2013)

Cytotoxicity of Goniothalamin on the Human Hepatocellular Carcinoma HEPG2 Cell Line
by: Obaid Al-Qubaisi, Mothanna Sadiq
Published: (2009)

Cytotoxic Effects of Methylgerambullin and Bis(Methylthiomethyl)-Disulphide (SB) on T-Lymphoblastic Leukemic Cell Line (Cem-SS)
by: Mohamed, Shar Mariam
Published: (2000)

Assessment of Chitosan Conditioning in a Synthetic Anaerobic Digested Sludge System
by: Lau, Shiew Wei, et al.
Published: (2014)

A Simple Surface-Complex Model (SCM) for Metal Ion Adsorption Mechanism
by: Sen, Tushar
Published: (2012)

Immediate early protein of equid herpesvirus type 1 as a target for cytotoxic T-lymphocytes in the thoroughbred horse
by: Kydd, Julia H., et al.
Published: (2014)

Immunomodulatory Effects of Rhaphidophora Korthalsii Methanol Extract on Natural Killer Cell Activation and Cytolytic Activity
by: Yeap, Swee Keong
Published: (2010)

Optimisation of Cell Cultures and Cytotoxic Activity of Pereskia Bleo (kunth) dc. Extracts
by: Sulong, Noor Anilizawatima
Published: (2011)

Shoot multiplication, microtuber production and evaluation of antioxidant and cancer cell cytotoxicity activities of chlorophytum borivilianum Sant. & Fernandez
by: Ashraf, Mehdi Farshad
Published: (2012)

Cytotoxicity and mode of action of Barrientosiimonas humi extract against breast cancer cell lines
by: Yeoh, Chiann Ying
Published: (2021)

Cytotoxicity of thymoquinone and thymoquinone-loaded nanostrustured lipid carrier on cervical cancer cells (SiHa and HeLa)
by: Ng, Wei Keat
Published: (2015)

Variation in structure and properties of poly(glycerol adipate) via control of chain branching during enzymatic synthesis
by: Taresco, Vincenzo, et al.
Published: (2016)

Preparation and characterisation of hyperbranched poly divinyl benzene and star branched poly lactic acid blends and their composites
by: Kabir, Sumaya Farhana
Published: (2017)

Cation solvation in the solid state - temperature-dependent crystal structures in some metal perchlorates solvated by dimethylsulfoxide
by: Chan, E., et al.
Published: (2004)

Dual-conditioning of Sludge using Chitosan and Metal Cations
by: Lau, Shiew Wei, et al.
Published: (2015)

Dual-Conditioning of Sludge using Chitosan and Metal Cations
by: Lau, Shiew Wei, et al.
Published: (2014)

Production of novel antimicrobial peptide human beta defensin 9 and its efficacy against common eye pathogenic bacteria in different salt concentration
by: Ab Hamid, Nurul Atikah
Published: (2018)

The effects of phenoxodiol on the cell cycle of prostate cancer cell lines
by: Mahoney, S., et al.
Published: (2014)

Alkyl-modified oligonucleotides as intercalating vehicles for doxorubicin uptake via albumin binding
by: Purdie, Laura, et al.
Published: (2018)

Isolation, structure elucidation and cytotoxic activity of cucurbitacins from Elaeocarpus petiolatus
by: Cho, Eun Seon
Published: (2019)

Development, characterization, cytotoxicity and antitumor effect of tamoxifen-loaded solid lipid nanoparticles
by: Abbasalipourkabirreh, Roghayeh
Published: (2010)

Cytotoxicity of Mahanimbine, Murryafoline A and S-Benzyldithiocarbazate on Human Leukemic Cell Line, CEM-SS
by: Kok, Yih Yih
Published: (2001)

Synthesis, characterization and cytotoxic study of Cu(II) and Ni(II) containing amino acid derived schiff bases
by: Abdul Aziz, Nur Fadhilah
Published: (2016)

Interaction potentials, spectroscopy and transport properties of C+(2PJ) and C+(4PJ) with helium
by: Tuttle, William D., et al.
Published: (2015)

Spectroscopic analysis of 1-butyl-2,3-dimethylimidazolium ionic liquids: cation-anion interactions
by: Men, Shuang, et al.
Published: (2017)

Interactions of C+(2PJ) with rare gas atoms: incipient chemical interactions, potentials and transport coefficients
by: Tuttle, William D., et al.
Published: (2018)

Effect of antipsychotics on mitochondrial bioenergetics of rat ovarian theca cells
by: Elmorsy, Ekramy, et al.
Published: (2017)

Isolation, structure, characterization and cytotoxicity assessment of alkaloids from Ficus fistulosa var. tengerenisis (Miq.) Kuntze
by: Al-Khdhairawi, A. A. Q.
Published: (2018)

Characterisation of Plant Derived Damnacanthal and Nordamnacantbal Induced Cytotoxicity on Human HT29 Colon Adenocarcinoma Cell Line
by: Khor, Tin Oo
Published: (2001)

Synthesis, characterization and in Vitro evaluation of manganese ferrite (MnFe2O4) nanopeprintss for their biocompatibility with murine breast cancer cells (4T1)
by: Kanagesan, Samikannu, et al.
Published: (2016)

Antimicrobial, immunomodulatory and tumor cells-selective cytotoxic activities of Brassica oleracea L. and Vigna radiata L
by: Hafidh, Rand R.
Published: (2011)

Characterization, pharmacokinetics, in vitro cytotoxicity of oxytetracycline-loaded CaCo₃ nanoparticle and its antibacterial and antibiofilm effects against Corynebacterium pseudotuberculosis isolated from goats
by: Banke, Idris Sherifat
Published: (2020)

Physicochemical characterization of palladium-, platinum-, silver-doped magnesia nanoparticles and in vitro cytotoxicity in A549 (lung) and HT29 (colon) cancer cell lines
by: Khlaif, Mohamed Qasim
Published: (2019)

Controlled polymerisation and purification of branched poly(lactic acid) surfactants in supercritical carbon dioxide
by: Goddard, Amy R., et al.
Published: (2016)

Activation of DMSO for Swern-type oxidation by 1,1-dichlorocycloheptatriene
by: Nguyen, Thanh Vinh, et al.
Published: (2014)