Densely functionalised spirocyclic oxetane-piperidine scaffolds for drug discovery
A spirocyclic, sp3-atom rich oxetane-containing scaffold was synthesised in just two steps via a gold catalysed propargylic alcohol rearrangement. The key gold cyclisation can be undertaken on a 40 g scale allowing the preparation of 419 lead-like compounds based on the scaffold for the European Lea...
| Main Authors: | , , , , , |
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| Format: | Article |
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Elsevier
2017
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| Online Access: | https://eprints.nottingham.ac.uk/49828/ |
| _version_ | 1848798087509704704 |
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| author | Geary, Gemma C. Nortcliffe, Andrew Pearce, Christopher A. Hamza, Daniel Jones, Geraint Moody, Christopher J. |
| author_facet | Geary, Gemma C. Nortcliffe, Andrew Pearce, Christopher A. Hamza, Daniel Jones, Geraint Moody, Christopher J. |
| author_sort | Geary, Gemma C. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | A spirocyclic, sp3-atom rich oxetane-containing scaffold was synthesised in just two steps via a gold catalysed propargylic alcohol rearrangement. The key gold cyclisation can be undertaken on a 40 g scale allowing the preparation of 419 lead-like compounds based on the scaffold for the European Lead Factory. |
| first_indexed | 2025-11-14T20:14:12Z |
| format | Article |
| id | nottingham-49828 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:14:12Z |
| publishDate | 2017 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-498282020-05-04T19:21:39Z https://eprints.nottingham.ac.uk/49828/ Densely functionalised spirocyclic oxetane-piperidine scaffolds for drug discovery Geary, Gemma C. Nortcliffe, Andrew Pearce, Christopher A. Hamza, Daniel Jones, Geraint Moody, Christopher J. A spirocyclic, sp3-atom rich oxetane-containing scaffold was synthesised in just two steps via a gold catalysed propargylic alcohol rearrangement. The key gold cyclisation can be undertaken on a 40 g scale allowing the preparation of 419 lead-like compounds based on the scaffold for the European Lead Factory. Elsevier 2017-12-08 Article PeerReviewed Geary, Gemma C., Nortcliffe, Andrew, Pearce, Christopher A., Hamza, Daniel, Jones, Geraint and Moody, Christopher J. (2017) Densely functionalised spirocyclic oxetane-piperidine scaffolds for drug discovery. Bioorganic & Medicinal Chemistry . ISSN 0968-0896 https://www.sciencedirect.com/science/article/pii/S0968089617321880?via%3Dihub doi:10.1016/j.bmc.2017.12.012 doi:10.1016/j.bmc.2017.12.012 |
| spellingShingle | Geary, Gemma C. Nortcliffe, Andrew Pearce, Christopher A. Hamza, Daniel Jones, Geraint Moody, Christopher J. Densely functionalised spirocyclic oxetane-piperidine scaffolds for drug discovery |
| title | Densely functionalised spirocyclic oxetane-piperidine scaffolds for drug discovery |
| title_full | Densely functionalised spirocyclic oxetane-piperidine scaffolds for drug discovery |
| title_fullStr | Densely functionalised spirocyclic oxetane-piperidine scaffolds for drug discovery |
| title_full_unstemmed | Densely functionalised spirocyclic oxetane-piperidine scaffolds for drug discovery |
| title_short | Densely functionalised spirocyclic oxetane-piperidine scaffolds for drug discovery |
| title_sort | densely functionalised spirocyclic oxetane-piperidine scaffolds for drug discovery |
| url | https://eprints.nottingham.ac.uk/49828/ https://eprints.nottingham.ac.uk/49828/ https://eprints.nottingham.ac.uk/49828/ |