Densely functionalised spirocyclic oxetane-piperidine scaffolds for drug discovery
A spirocyclic, sp3-atom rich oxetane-containing scaffold was synthesised in just two steps via a gold catalysed propargylic alcohol rearrangement. The key gold cyclisation can be undertaken on a 40 g scale allowing the preparation of 419 lead-like compounds based on the scaffold for the European Lea...
| Main Authors: | , , , , , |
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| Format: | Article |
| Published: |
Elsevier
2017
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| Online Access: | https://eprints.nottingham.ac.uk/49828/ |