Is tapentadol different from classical opioids?: a review of the evidence

QR Code

Is tapentadol different from classical opioids?: a review of the evidence

Tapentadol is a single molecule able to deliver analgesia by two distinct mechanisms, a feature which differentiates it from many other analgesics. Pre-clinical data demonstrate two mechanisms of action: mu-opioid receptor agonist activity and noradrenaline re-uptake inhibition. From these, one may...

Full description

Bibliographic Details
Main Authors:	Langford, Richard M., Knaggs, Roger, Farquhar-Smith, Paul, Dickenson, Anthony H.
Format:	Article
Published:	SAGE 2016
Subjects:	Tapentadol opioids pain pharmacology analgesics analgesic mechanisms of action
Online Access:	https://eprints.nottingham.ac.uk/49225/

Similar Items

Prescribing opioid analgesics for chronic non-malignant pain in general practice - a survey of attitudes and practice
by: Blake, Holly, et al.
Published: (2015)

In vivo Evaluation of Analgesic, Anti-Inflammatory and Antipyretic Activities of Aqueous Extract from Tamarindus Indica l. Fruit
by: Md Khalid, Syamimi Md Khalid
Published: (2011)

Evaluation of antinociceptive activity of 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol and its possible mechanisms of action in mice
by: Ong, Hui Ming
Published: (2021)

Evaluation of antinociceptive and analgesic properties of tramadol in cats
by: Basiri, Bita
Published: (2013)

In vivo evaluation of antinociceptive activities of 2-benzoyl-6-(3,4-dihydroxybenzylidene)cyclohexen-1-Ol and its possible mechanism of actions
by: Ahmad Azmi, Ahmad Farhan
Published: (2021)

A meta-analysis of gabapentin and multimodal analgesics
by: Doleman, Brett
Published: (2017)

Preliminary analysis of the antinociceptive activity of zerumbone
by: Sulaiman, Mohd Roslan, et al.
Published: (2009)

Post-surgical analgesic properties and pharmacokinetics of tramadol in dogs undergoing elective surgery
by: Buhari, Salisu
Published: (2012)

Investigating the association between opioid analgesics and the risk of bone fracture
by: Peach, Emily J.
Published: (2020)

Evaluation of opioid-related deaths associated with opioid utilisation and the impacts of tramadol classification as a Schedule III Controlled Drug in the United Kingdom
by: Chen, Teng-Chou
Published: (2019)

An exploration of strong opioid utilisation in non-cancer pain patients in UK primary care, 2000-2010
by: Adan Hag Hersi, Muna
Published: (2018)

Prescribed opioid use is associated with adverse cardiovascular outcomes in community-dwelling older persons
by: Liew, S.M., et al.
Published: (2022)

Antinociceptive and Anti-Inflammatory Activities of Zerumbone from Zingiber Zerumbet (l.) Roscoe ex sm., and its Possible Mechanisms of Action
by: Perimal, Enoch Kumar
Published: (2012)

Role of Community Pharmacists in Optimizing Opioid Therapy for Chronic Non-malignant Pain Patients in Pakistan
by: Iqbal, Ayesha
Published: (2023)

Design and synthesis of fluorescent opioids for bioimaging
by: Lam, Raymond
Published: (2018)

Postoperative pain assessment, and opioid utilisation after hospital discharge following colectomy
by: Baamer, Reham
Published: (2024)

“If you can’t see a dilemma in this situation you should probably regard it as a warning”: a metasynthesis and theoretical modeling of general practitioners' opioid prescription experiences in primary care
by: Kennedy, Mary-Claire, et al.
Published: (2018)

Design, synthesis and pharmacological evaluation of novel fluorescent ligands for the mu-opioid receptor
by: Marshall, William
Published: (2021)

New chemistry to support the search for more effective opioids
by: Yang, Ruoyan
Published: (2020)

Patterns of initial opioid prescribing and its association with short and long-term use among opioid naïve patients: Experience from Malaysia
by: Zin, Che Suraya, et al.
Published: (2018)

Working together: Expanding the availability of naloxone for peer administration to prevent opioid overdose deaths in the Australian Capital Territory and beyond
by: Lenton, Simon, et al.
Published: (2014)

Prescribing of Strong Opioid Analgesics by UK Primary Care Physicians from 2000 to 2010
by: Zin, Che Suraya, et al.
Published: (2012)

Characteristics, retention and readmissions of opioid-dependent clients treated with oral naltrexone
by: Bartu, Anne, et al.
Published: (2002)

Differential patterns of adherence to opioid therapy in opioid naïve and opioid existing patients with different age groups
by: Zin, Che Suraya, et al.
Published: (2019)

Is maternal therapeutic opioid use instigating misdiagnosis in breastfed infants? A case report
by: Ahmadzai, Hilai, et al.
Published: (2020)

Commentary on Williams et al. (2014): Family matters—new resources for managing opioid overdose with take-home naloxone
by: Tait, Robert, et al.
Published: (2014)

The future of osteoarthritis therapeutics: targeted pharmacological therapy
by: Mobasheri, Ali
Published: (2013)

Prevalence and associated factors of opioid relapse among methadone maintenance therapy patients in Johor Bahru government health clinics, Malaysia
by: Mohmad, Faradia
Published: (2021)

Investigation of plasma concentrations of IL-6 and IL-10 in short and long-term opioid users with non-cancer pain
by: Zin, Che Suraya, et al.
Published: (2018)

Sex differences in high opioid dose escalation among Malaysian patients with long term opioid therapy
by: Zin, Che Suraya, et al.
Published: (2019)

Novel Approaches Towards the Synthesis of Morphinan Derivatives
by: Gorbachev, Dmitry
Published: (2023)

Clinical, behavioural and social indicators of suicide risk: a population-based nationally representative longitudinal study from England.
by: Alothman, Danah
Published: (2024)

Describing the characteristics, treatment pathways, outcomes, and costs of people with persistent noncancer pain managed by community pain clinics and generating an indicative estimate of cost-effectiveness: feasibility study protocol
by: AlAujan, Shiekha, et al.
Published: (2016)

Bidirectional association between disturbed sleep and neuropathic pain symptoms: a prospective cohort study in post-total joint replacement participants
by: Stocks, Joanne, et al.
Published: (2017)

A bibliometric analysis of opioid in Malaysia
by: Zin, Che Suraya, et al.
Published: (2020)

What's the role of the amygdala in chronic pain?: evidence from magnetic resonance imaging studies in humans
by: Drabek, Marianne Marta
Published: (2020)

A bibliometric analysis on the productivity of opioid research in Malaysia
by: Zin, Che Suraya, et al.
Published: (2019)

Development of clinical protocol for Ibogaine administration as anti addictive treatment in opioid addiction
by: Syed Mohmad Paudzi, Syed Mohd Syahmi, et al.
Published: (2016)

Global metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii
by: Mahamad Maifiah, Mohd Hafidz, et al.
Published: (2016)

Comparison of the clinical outcomes between short-term and long-term opioid users with noncancer pain at pain clinics
by: Abdullah Sani, Asween Rowena, et al.
Published: (2020)