Therapeutic concentrations of antidepressants inhibit pancreatic beta-cell function via mitochondrial complex inhibition

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Therapeutic concentrations of antidepressants inhibit pancreatic beta-cell function via mitochondrial complex inhibition

Diabetes mellitus risk is increased by prolonged usage of antidepressants (ADs). Although various mechanisms are suggested for their diabetogenic potential, whether a direct effect of ADs on pancreatic β-cells is involved is unclear. We examined this idea for 3 ADs: paroxetine, clomipramine and, wit...

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Bibliographic Details
Main Authors:	Elmorsy, Ekramy, Al-Ghafari, Ayat, Helaly, Ahmed, Hisab, Ahmed S., Oehrle, Bettina, Smith, Paul A.
Format:	Article
Published:	Oxford University Press 2017
Subjects:	antidepressant diabetes mellitus beta-cell mitochondria cytotoxicity fluoxetine
Online Access:	https://eprints.nottingham.ac.uk/43309/

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